Evidence map›Paper›PMID 41230162›Full record

ArticleTranslational andrology and urology2025

Sparing urethra in women at the time of cystectomy: retrospective comparison of cystectomies with and without urethrectomy.

Andres Matoso, Sonia Kamanda, Sunil Patel, Meghan McNamara, Shirley Wang, Kara A Lombardo, Jean Hoffman-Censits, Max Kates, Rodrigo Salgado Esteves, Armine Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andres MatosoDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-0990-1115
Sonia KamandaDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Sunil PatelDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Meghan McNamaraDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Shirley WangDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Kara A LombardoDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Jean Hoffman-CensitsDepartment of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Max KatesDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Rodrigo Salgado EstevesDepartment of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Armine SmithDepartment of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-3846-0235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In female patients undergoing cystectomy where orthotopic bladder reconstruction is not an option, urethrectomy is typically performed. Unlike in males, female urethrectomy carries a risk of damaging clitoral structures and nerves, potentially contributing to post-cystectomy sexual dysfunction. This study evaluates overall survival in women undergoing cystectomy with versus without urethrectomy. Methods: A retrospective review of electronic medical records from 2000 to 2023 was conducted. Radical cystectomy specimens were reviewed for surgical details, tumor characteristics, urethral involvement, and urethrectomy status. Institutional criteria required urethrectomy in patients receiving neobladder reconstruction. Results: Among 347 women who underwent cystectomy, 298 received urethrectomy and 49 did not. The mean age was 65.4 years. Urethral involvement was present in 15 cases (7%). One patient with a neobladder and positive urethral margin remained disease-free at 5 years. At the last follow-up, 54.2% of patients with urethrectomy and 61.2% without urethrectomy showed no evidence of disease. A total of 76 patients (26.5%) were alive with disease, 62 (20.8%) in the urethrectomy group and 14 (28.6%) in the non-urethrectomy group. Kaplan-Meier analysis showed mean overall survival of 246.9 months with urethrectomy Conclusions: Urethra-sparing cystectomy in women may be oncologically safe when no urethral involvement is present and should be considered to preserve sexual function.

Indexed as

bladder cancercystectomyfemaleUrethrectomy

Identifiers

PMID41230162
PMCPMC12603828

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.