ArticleTranslational andrology and urology2025
Impact of preoperative SARS-CoV-2 infection on post-prostatectomy urinary continence and erectile function.
Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Urinary incontinence (UI) and erectile dysfunction (ED) are common sequelae after radical prostatectomy (RP), substantially affecting patients' quality of life. Since the coronavirus disease 2019 (COVID-19) pandemic, increasing attention has been given to the potential systemic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including endothelial dysfunction and hormonal alterations, which may influence functional recovery after surgery. This study aimed to investigate the impact of preoperative SARS-CoV-2 infection on postoperative urinary continence and erectile function in prostate cancer patients. Methods: A retrospective cohort of 298 patients undergoing RP was stratified into COVID-19 infected (n=166) and non-infected (n=132) groups based on preoperative reverse transcription polymerase chain reaction (RT-PCR) results. Functional outcomes were assessed using the International Index of Erectile Function-5 (IIEF-5) and Incontinence Quality of Life (I-QOL) scores at 6 months postoperatively. Results: At 6-month postoperative follow-up, the COVID-19 group had significantly lower IIEF-5 scores compared to controls in univariable analysis (median: 11 Conclusions: Preoperative COVID-19 infection was linked to reduced erectile function in univariable analysis but not after multivariable adjustment, and it had no significant effect on urinary continence. Sexual and urinary function were correlated in both groups, but this relationship was not modified by COVID-19 status.
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