Evidence map›Paper›PMID 41230141›Full record

ArticleTranslational andrology and urology2025

Clinicopathological features and prognostic factors of clear cell papillary renal cell tumor: a retrospective population-based analysis.

Yiguan Qian, Kunlun Zhao, Yang Li, Ning Liu, Chencheng Ji, Paerhati Tuerxun, Xiaotian Jiang, Min Wang, Zhongli Xiong, Ruipeng Jia and 2 more

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In one paragraph

Article in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yiguan Qian *Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Kunlun Zhao *Department of Urology, Yining People's Hospital, Yining, China.
Yang Li *Department of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ning LiuDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Chencheng JiDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Paerhati TuerxunDepartment of Urology, Yining People's Hospital, Yining, China.
Xiaotian JiangDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Min WangDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Zhongli XiongDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Ruipeng JiaDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Tao XuGeneral Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.
Yu-Zheng GeDepartment of Urology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.ORCID https://orcid.org/0000-0003-1615-9473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Clear cell papillary renal cell tumor (ccpRCT) is a novel tumor entity which shares morphologic features with clear cell renal cell carcinoma (ccRCC) and papillary RCC (pRCC). The aim of this study was to comprehensively explore the clinicopathological features and prognostic factors of ccpRCT in the real-world setting with the largest cohort to date. Methods: A total of 59,076 eligible RCC patients diagnosed between 2016 and 2021 in the Surveillance, Epidemiology, and End Results database were included in this retrospective analysis. The demographic and clinicopathological variables of ccpRCT patients were compared to those of ccRCC or pRCC patients. The survival curves were generated via the Kaplan-Meier method. The Cox proportional hazards model was used to compare the differences in overall survival (OS) and disease-specific survival (DSS). Results: Compared with ccRCC and pRCC patients, those with ccpRCT were more frequently diagnosed with lower grade (G1/2) and lower stage (I/II), and exhibited prolonged OS and DSS. Univariate Cox regression analysis revealed that age at diagnosis; histological grade; tumor (T), node (N), metastasis (M) and overall stage; treatment type; and history of cancer were significantly associated with both OS and DSS. In addition, age at diagnosis and treatment type were crucial prognostic factors in terms of both OS and DSS according to multivariate Cox regression analysis. Conclusions: Our study demonstrated the highly favorable outcomes in ccpRCT patients with low potential of lymph node invasion, metastasis, or disease specific death, and surgery is associated with improved outcomes.

Indexed as

clear cell papillary renal cell tumor (ccpRCT)clinicopathological featuresprognostic factorsRenal cell carcinoma (RCC)

Identifiers

PMID41230141
PMCPMC12603853

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