Evidence map›Paper›PMID 41230130›Full record

ReviewTranslational andrology and urology2025

Complications and management of penile enhancement procedures.

Michael Pignanelli, J Matt Williams, Raul E Fernandez Crespo, Jacob Britt, Justin Parker, Rafael Carrion

Abstract readReview
In one paragraph

Review in Translational andrology and urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Michael PignanelliDepartment of Urology, Albany Medical College, Albany, NY, USA.
J Matt WilliamsDepartment of Urology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Raul E Fernandez CrespoDepartment of Urology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Jacob BrittDepartment of Urology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Justin ParkerDepartment of Urology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Rafael CarrionDepartment of Urology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Demand for penile enhancement-driven by cosmetic and psychological goals-is rising, and complications are increasingly encountered in urologic practice. This review offers practical, procedure-focused guidance on diagnosing and managing adverse events after injectable fillers, self-injection of foreign substances, dermal matrices, autologous fat transfer, and the subcutaneous silicone Penuma implant. Hyaluronic acid (HA) is the most commonly used filler and, when applied with standardized, low-volume protocols, generally has lower complication rates than polylactic acid (PLA), polymethylmethacrylate (PMMA), silicone, or nonmedical self-injected materials. Typical HA-related issues include migration, nodules, Tyndall effect, phimosis, and infection; management emphasizes early massage/modeling, warm compresses, judicious hyaluronidase for confirmed HA, antibiotics with drainage for abscess, and selective surgical excision for refractory nodules. Permanent fillers and self-injected substances are associated with granuloma, necrosis, infection, lymphedema, and disfiguring inflammation; these often require wide excision down to Buck's fascia with reconstructive strategies such as split-thickness skin grafts or scrotal/dartos flaps. For dermal matrix and fat transfer, complications include edema, hematoma, infection (commonly

Indexed as

complicationshyaluronic acid (HA)penile girth enhancementpenile injectionsPenuma

Identifiers

PMID41230130
PMCPMC12603848

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.