Evidence map›Paper›PMID 41230110›Full record

ArticleResearch (Washington, D.C.)2025

An Attack and Defense Strategy for Osteoarthritis Repair: Constructing a Trace Element Modulated Hydrogel to Mitigate Ferroptosis and Promote Cartilage Matrix Reconstruction.

Wenhui Hu, Fei Kang, Yuheng Li, Yixiang Xu, Xiaoming Li, Jing Zhang, Jie Liao, Jingjin Dai, Xiaoshan Gong, Jianmei Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenhui HuDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Fei KangDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Yuheng LiDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Yixiang XuDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Xiaoming LiDepartment of Military Traffic Medicine, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Jing ZhangCollege of Bioengineering, Chongqing University, Chongqing 400044, China.
Jie LiaoDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Jingjin DaiDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Xiaoshan GongDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Jianmei LiDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.
Xuan YaoDepartment of Clinical Hematology, Faculty of Laboratory Medicine, Third Military Medical University, Chongqing 400038, China.
Shiwu DongDepartment of Biomedical Materials Science, College of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China.ORCID https://orcid.org/0000-0002-5032-4893

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritic cartilage tissue displays a characteristic imbalance in trace element metabolism closely associated with the production of oxidative stress. This study revealed the pivotal role of iron-overload-triggered and selenoprotein-catalyzed lipid peroxidation in osteoarthritis pathogenesis. Based on this discovery, we innovatively pioneered the integration of Fe

Identifiers

PMID41230110
PMCPMC12604057

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.