Evidence map›Paper›PMID 41230037›Full record

ArticleInternational journal of pharmaceutics: X2025

A comparative study on stevioside- and rubusoside-assisted micellar solubilization of clofazimine for physicochemical and

Seong-Jin Hong, Hye-Su An, Bo-Ram Park, Ki-Nam Yoon, Hye-Jin Kang, Sung Jae Shin, Young-Min Kim

Abstract read
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In one paragraph

Article in International journal of pharmaceutics: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seong-Jin HongResearch Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
Hye-Su AnDepartment of Microbiology, Institute for Immunology and Immunological Disease, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Bo-Ram ParkDepartment of Agro-Food Resources, National Institute of Agricultural Sciences, Rural Development Administration, Jeonju 55365, Republic of Korea.
Ki-Nam YoonResearch Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
Hye-Jin KangResearch Institute of Agricultural Science and Technology, Chonnam National University, Gwangju 61186, Republic of Korea.
Sung Jae ShinDepartment of Microbiology, Institute for Immunology and Immunological Disease, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Young-Min KimDepartment of Integrative Food, Bioscience and Biotechnology, Chonnam National University, Gwangju 61186, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study compares the micellization and encapsulation abilities of stevioside (STE) and rubusoside (RUB) for enhancing the solubility, stability, and bioavailability of clofazimine (CFZ), a poorly water-soluble antibiotic. CFZ-loaded micelles were prepared and characterized by FT-IR, XRD, DSC, SEM, and NMR. RUB showed a lower critical micelle concentration and significantly improved CFZ solubility (up to 2.06 mg/mL) compared to STE. CFZ-RUB complexes offered greater protection against UV and oxidative degradation.

Indexed as

ClofazimineMicelleRelease propertiesRubusosideStevioside

Identifiers

PMID41230037
PMCPMC12603695

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.