Evidence map›Paper›PMID 41230027›Full record

ArticleJournal of the Endocrine Society2025

Association of Neck Circumference With Cardiometabolic Risk Factors and Diseases in the German National Cohort.

Eike A Strathmann, Ilka Ratjen, Klara Willrodt, Janna Enderle, Sabrina Schlesinger, Beate Fischer, Katharina S Weber, Cara Övermöhle, Karin H Greiser, Anja M Sedlmeier and 5 more

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eike A StrathmannInstitute of Epidemiology and Biobank popgen, Christian-Albrechts-University, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.ORCID https://orcid.org/0009-0004-5239-1346
Ilka RatjenClinic for Internal Medicine II, Hematology and Oncology, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.
Klara WillrodtInstitute of Epidemiology and Biobank popgen, Christian-Albrechts-University, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.
Janna EnderleInstitute for Human Nutrition and Food Science, Christian-Albrechts-University, Kiel 24105, Germany.
Sabrina SchlesingerInstitute for Biometrics and Epidemiology, German Centre for Diabetes, Heinrich-Heine-University, Düsseldorf 40225, Germany.ORCID https://orcid.org/0000-0003-4244-0832
Beate FischerInstitute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg 93053, Germany.
Katharina S WeberInstitute of Epidemiology and Biobank popgen, Christian-Albrechts-University, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.
Cara ÖvermöhleInstitute of Epidemiology and Biobank popgen, Christian-Albrechts-University, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.
Karin H GreiserDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Anja M SedlmeierInstitute for Epidemiology and Preventive Medicine, University of Regensburg, Regensburg 93053, Germany.
Margit HeierInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Neuhersberg 85764, Germany.
Anna KöttgenInstitute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg 79106, Germany.
Kathrin GüntherDepartment of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology-BIPS, Bremen 28359, Germany.
Matthias NauckInstitute for Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Wolfgang LiebInstitute of Epidemiology and Biobank popgen, Christian-Albrechts-University, University Hospital Schleswig-Holstein Campus Kiel, Kiel 24105, Germany.ORCID https://orcid.org/0000-0003-2544-4460

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Neck circumference (NC) was proposed as promising marker to assess body fat distribution and cardiometabolic risk. Objective: We aimed to assess associations of NC with anthropometric traits, cardiometabolic risk markers, and self-reported cardiometabolic diseases. Methods: NC was measured in a subsample (5865 participants) of the German National Cohort (NAKO Gesundheitsstudie, NAKO), study region Kiel. Linear and logistic regression models were applied to assess associations of NC with anthropometric and cardiometabolic risk markers and self-reported cardiometabolic diseases, including diabetes, heart failure, gout, and a composite end point "clinical CVD" (cardiovascular disease; combining history of angina pectoris, stroke, myocardial infarction, and peripheral artery disease). Models were adjusted for sex and age, CV risk factors (systolic blood pressure, diabetes, low-density lipoprotein [LDL] cholesterol, use of lipid-lowering and antihypertensive medication, smoking status), and body mass index (BMI). Results: Mean NC values (±SD) were 39.5 ± 3.0 in men and 33.6 ± 2.7 cm in women. NC was positively associated with anthropometric traits, visceral adipose tissue (cm) (β = 1.45 [95% CI, 0.88-2.02]), systolic (β = .37 [0.19-0.56]) and diastolic (β = .17 [0.05-0.29]) blood pressure, glycated hemoglobin A Conclusion: NC was associated with several cardiometabolic risk factors, including glycemic and lipid traits and self-reported cardiometabolic diseases. These observations suggest that NC may be a useful surrogate marker for cardiometabolic risk.

Indexed as

cardiometabolic risk factorscardiovascular diseasediabetesGerman National Cohortmetabolic diseaseNAKO

Identifiers

PMID41230027
PMCPMC12603556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.