Evidence map›Paper›PMID 41229963›Full record

ArticleRSC advances2025

The synthesis of indomethacin prodrugs for the formation of nanosuspensions by emulsion templated freeze drying.

Jessica Taylor, Andrew Sharp, Steve P Rannard, Sarah Arrowsmith, Tom O McDonald

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jessica TaylorDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK.
Andrew SharpHarris-Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, Liverpool Women's Hospital, University of Liverpool Crown Street Liverpool L8 7SS UK.
Steve P RannardDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK.ORCID https://orcid.org/0000-0002-6946-1097
Sarah ArrowsmithHarris-Wellbeing Preterm Birth Research Centre, Department of Women's and Children's Health, Liverpool Women's Hospital, University of Liverpool Crown Street Liverpool L8 7SS UK.
Tom O McDonaldDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK.ORCID https://orcid.org/0000-0002-9273-9173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emulsion-templated freeze drying (ETFD) is a versatile technique for producing nanosuspensions of poorly water-soluble drugs, but predicting formulation success remains a significant challenge. In this study, we investigate how structural modification of the model drug indomethacin, through esterification with a series of alkyl and aromatic groups, influences nanosuspension formation

Identifiers

PMID41229963
PMCPMC12603901

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.