Evidence map›Paper›PMID 41229954›Full record

ArticleRSC advances2025

Molecular insights into nilvadipine-hemoglobin interactions: conformational dynamics and binding mechanisms.

Mohd Shahnawaz Khan, Md Tabish Rehman, Nojood Al-Twaijry, Nouf Omar Alafaleq, Ibrahim Aldobiyan, Majed S Alokail, Areej Ali Alzahrani, Mohammed Arshad, Mohammad F AlAjmi

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Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mohd Shahnawaz KhanDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.ORCID https://orcid.org/0000-0002-4599-5924
Md Tabish RehmanDepartment of Pharmacognosy, College of Pharmacy, King Saud University Riyadh 11451 Saudi Arabia.
Nojood Al-TwaijryDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.
Nouf Omar AlafaleqDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.
Ibrahim AldobiyanDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.
Majed S AlokailDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.
Areej Ali AlzahraniDepartment of Biochemistry, College of Science, King Saud University Riyadh 11451 Saudi Arabia moskhan@ksu.edu.sa.
Mohammed ArshadDental Health Department, College of Applied Medical Science, King Saud University Riyadh 11451 Saudi Arabia.
Mohammad F AlAjmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University Riyadh 11451 Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the molecular basis of drug-protein interactions is essential for predicting pharmacokinetics and potential off-target effects. Here, we employ a combined experimental and computational approach to characterize the binding of Nilvadipine (a dihydropyridine calcium channel blocker) to hemoglobin (Hb). Using Soret band absorption and steady-state fluorescence spectroscopy across 298-310 K, we observed pronounced static quenching of Hb's intrinsic fluorescence, yielding Stern-Volmer constants (

Identifiers

PMID41229954
PMCPMC12604001

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.