Evidence map›Paper›PMID 41229853›Full record

ArticleJournal of thoracic disease2025

Protective effects of estradiol on neuroinflammation in chronic obstructive pulmonary disease related depression.

Jianing Lu, Yuanyuan Li, Zili Zhang, Jingyi Xu, Guizhen Zhang, Xiaoyan Luo, Haichun Zheng, Wenju Lu, Qinghui Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianing Lu *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Yuanyuan Li *State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Zili ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Jingyi XuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Guizhen ZhangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Xiaoyan LuoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Haichun ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Wenju LuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Qinghui HuangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Depression among women with chronic obstructive pulmonary disease (COPD) has garnered significant attention. The role of estradiol (E2) on COPD-related depression is unknown. Therefore, this study aimed to investigate the role and underlying mechanism of E2 in COPD related depression. Methods: Female and ovariectomized (OVX) Sprague-Dawley rats (SD rats) were exposed to cigarette smoke (CS) to establish a COPD model. At the end of the experiment, behavioral tests to assess behavioral alterations were tested, pulmonary functions were measured, lung and brain tissue were observed for pathological change. Additionally, we evaluated the levels of oxidative stress and inflammation-related proteins of brain tissue. Results: COPD rats exhibited depression-like behavior, accompanied by a significant decrease in 5-hydroxytryptamine (5-HT) levels in the plasma and cerebral cortex. The combination of OVX and CS exposure resulted in a rat model of COPD-related depression. In this model, brain microglia and astrocytes were activated, with increased expression of nuclear factor erythroid 2-related factor-2 (Nrf2), quinone oxidoreductase 1 (NQO1), heme-oxygenase-1 (HO1), and phosphorylated nuclear factor kappa B (p-NFκB) proteins, alongside enhanced M1 polarization in microglia. These changes were correlated with the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and c-Jun-N-terminal kinase (JNK). Conclusions: Our findings indicate that E2 protects against depression-like behavior induced by CS, which may be related to the activation of microglia and M1 polarization through the ERK1/2 and JNK pathways. Furthermore, estrogen levels appear to play a crucial role in the anti-neuroinflammatory processes associated with the onset and progression of depression in COPD.

Indexed as

chronic obstructive pulmonary disease (COPD)depressionEstradiol (E2)microglianeuroinflammation

Identifiers

PMID41229853
PMCPMC12603468

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.