ArticleJournal of thoracic disease2025
Global trends and hotspots of tumor necrosis factor-alpha in pulmonary tuberculosis: a bibliometric and visualization analysis.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tumor necrosis factor-alpha (TNF-α) plays a dual role in pulmonary tuberculosis, mediating protective immune responses while also contributing to pathological tissue damage. This dichotomy has attracted considerable research interest in recent years. Nevertheless, a comprehensive bibliometric analysis in this specific field remains lacking. The present study aims to fill this gap by examining global research trends and identifying emerging hotspots related to TNF-α in pulmonary tuberculosis through bibliometric methods. Methods: Relevant literature published between 1990 and 2024 was retrieved from the Web of Science Core Collection (WoSCC) database. VOSviewer, CiteSpace, and R 4.3.3 were utilized for the analysis. Results: A total of 1,200 articles were included in this study. The annual number of publications has consistently increased since 1990, with an average annual growth rate of 10.73%. These articles were authored by 6,129 researchers affiliated with 1,581 institutions across 83 countries/regions. The United States emerged as the leading contributor, ranking first in both total publications (TP =277) and citations [14,911]. The Indian Council of Medical Research was the most productive institution, with 83 articles. Kaplan G. was identified as the most influential author, ranking first in total citations (TC =2,348) and achieving an H-index of 17. The Conclusions: This bibliometric analysis underscores the evolving focus of TNF-α research in pulmonary tuberculosis, transitioning from foundational studies on immune mechanisms to applied research aimed at diagnostics and biomarkers. Future research should aim to validate the effectiveness of TNF-α gene markers across different populations and disease stages, investigate their molecular mechanisms and interactions with other cytokines, and work towards optimizing personalized treatments and improving clinical management outcomes.
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