ArticleJournal of thoracic disease2025
High PD-L1 expression correlates with lymph node metastasis in patients who have undergone radical surgery for primary pulmonary adenocarcinoma.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: As the use of immune checkpoint inhibitors in postoperative adjuvant chemotherapy for patients with programmed death-ligand 1 (PD-L1)-expressing lung cancer has been increasing, it is important to accumulate knowledge on PD-L1. In this study, we retrospectively evaluated PD-L1 expression and the related background characteristics in patients who underwent radical surgery for primary pulmonary adenocarcinoma. Methods: Of 673 non-small cell lung cancer (NSCLC) cases that underwent surgery at Iwate Medical University from January 2017 to December 2022, 453 cases were eligible for study participation. The cases were divided into three groups based on postoperative pathological diagnosis as PD-L1 tumor proportion score (TPS) of less than 1% (negative), 1-49% (low), and 50% or more (high), respectively. Results: There were 263 patients in the negative group, 133 in the low group, and 57 in the high PD-L1 group. Comparative analysis between the high and low/negative groups revealed statistically significant differences in gender, Brinkman Index, carcinoembryonic antigen (CEA), maximum standard uptake value (SUV-max), visceral pleural invasion, venous invasion, Conclusions: High PD-L1 expression correlates with lymph node metastasis and SUV-max in patients who underwent radical surgery for primary pulmonary adenocarcinoma. Lymph node metastasis and high SUV-max were identified as a potential independent risk factor for postoperative recurrence and might be a risk factor for recurrence in the postoperative period.
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