ArticleJournal of thoracic disease2025
Clinical characteristics and treatment challenges of esophageal sarcomatoid carcinoma: a single-center retrospective cohort study.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical features and prognostic factors for spinal metastasis from sarcomatoid carcinoma: identifying candidates suitable for surgical intervention.BMC musculoskeletal disorders · 2026Article
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9 authors.
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Abstract
Background: Esophageal sarcomatoid carcinoma (ESC) is an extremely rare malignant tumor of the esophagus, characterized by high malignancy, a propensity for metastasis, and poor prognosis. This retrospective study aims to analyze the clinicopathological features and prognostic factors of patients with ESC. Methods: We retrospectively analyzed the clinicopathological characteristics of 57 patients with ESC who underwent surgical treatment at the Cancer Hospital, Chinese Academy of Medical Sciences between January 2000 and December 2021. Survival analysis was performed using Kaplan-Meier curves, and prognostic factors were evaluated using univariate and multivariate Cox regression analyses. Results: The mean age of the cohort was 59.07±8.24 years, with males accounting for 84.2%. Eight patients (14%) were correctly diagnosed with ESC through preoperative endoscopic biopsy. ESC occurred in the middle third of the esophagus in 63.2% of cases. Postoperative tumor recurrence or metastasis mainly occurred within the second year, predominantly involving regional lymph node metastasis. Univariate and multivariate Cox analyses indicated that lymph node metastasis was an independent prognostic factor for ESC. Different surgical approaches and the use of adjuvant therapy did not improve the prognosis of ESC patients. Conclusions: The preoperative pathological diagnosis rate of ESC is low, and lymph node metastasis is associated with a poorer prognosis. Early screening and improving the accuracy of biopsy may be effective strategies for the diagnosis and treatment of ESC. Treatment approaches similar to those for esophageal cancer may not be suitable for ESC; therefore, specific treatment protocols for ESC need to be developed.
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