ArticleJournal of thoracic disease2025
Patients with multivalvular infective endocarditis demonstrate adverse cardiac remodeling before surgery with increased postoperative mortality risk.
Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Infective endocarditis can result in the destruction of any valve in the heart or damage to multiple valves. However, the scope of valvular damage is not considered in the current guidelines for surgical indications of infective endocarditis. Whether widespread valvular damage in infective endocarditis leads to more severe cardiac remodeling requiring earlier intervention remains unclear. We sought to investigate differences in adverse cardiac remodeling and postoperative outcomes in patients with infective endocarditis involving a single valve versus multiple valves. Methods: From January 2010 to December 2022, 343 patients with infective endocarditis who underwent valve surgery in Beijing Anzhen Hospital were included in our study. The patients were divided into multivalvular infective endocarditis group (n=143) and single-valve infective endocarditis group (n=200) according to the results of preoperative transthoracic echocardiography combined with actual repair or replacement of valves during surgery. Postoperative outcomes of the two groups were compared before and after inverse probability of treatment weighting (IPTW) treatment of baseline data. The primary endpoint was all-cause death and the secondary endpoint was a composite event including death, stroke, reoperation, and recurrence of infective endocarditis. Preoperative echocardiography comprehensively evaluated left ventricular diastolic and systolic function and cardiac remodeling. Results: The follow-up time of multivalvular infective endocarditis group and single-valve infective endocarditis group was respectively 47.93 and 69.98 months. Left ventricular end-diastolic diameter (6.1 Conclusions: Compared with patients with single-valve infective endocarditis, patients with multivalvular infective endocarditis demonstrated more pronounced preoperative left ventricular remodeling trends, lower postoperative survival rates, and reduced event-free survival rates. We propose that patients with multivalvular infective endocarditis may benefit from enhanced cardiac ultrasound surveillance and early surgical intervention before cardiac remodeling progress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.