Evaluating the effectiveness of staged versus simultaneous bilateral lung volume reduction surgery in patients with severe emphysema.

Background: Lung volume reduction surgery (LVRS) is an effective treatment for patients with severe emphysema. Most studies favor a bilateral approach over unilateral LVRS. However, there is limited literature comparing the outcomes of sequential bilateral "staged" versus simultaneous bilateral LVRS. Here, we evaluated the safety and effectiveness of these two approaches. Methods: This retrospective cohort study included patients with severe emphysema who underwent LVRS at two tertiary referral centers. Pre- and postoperative-pulmonary function tests were used to assess outcomes. Descriptive statistics were used to explore associations between variables. For our survival analysis, we created a composite outcome combining overall survival and transplant-free survival, which was analyzed using Kaplan-Meier estimate and log-rank test. Cox proportional-hazard models identified factors associated with the composite outcome. Results: The study included 81 patients, the majority of whom were male (n=42, 52%) with a median age of 65 years [interquartile range (IQR), 61-69 years]. Most underwent bilateral LVRS (n=60, 74%) while 21 (26%) had a staged approach. Baseline characteristics were similar between groups, except for age, with the bilateral group being significantly younger (P=0.03). Hospital length of stay was comparable between the bilateral {10.9 days [standard deviation (SD): 8.13] and staged LVRS groups [13.5 days (SD: 13.2)]} (P=0.40). Rates of pneumonia (13% Conclusions: Staged LVRS offered similar hospital length of stay and complication rates as bilateral LVRS. Both approaches led to clinically significant improvements in pulmonary function. Notably, the staged approach showed a better composite outcome of overall survival and transplant-free survival over simultaneous bilateral LVRS.