Evidence map›Paper›PMID 41229754›Full record

ArticleJournal of thoracic disease2025

Physical activity reduces cancer mortality but not cardiovascular or all-cause mortality in obstructive sleep apnea: a National Health and Nutrition Examination Survey (NHANES)-based analysis.

Liwen Chen, Liangfeng Liu, Guanwen He, Yangbin Xu, Rifu Wei

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Article in Journal of thoracic disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Liwen Chen *Ningde Clinical Medical College of Fujian Medical University, Ningde, China.
Liangfeng Liu *Ningde Clinical Medical College of Fujian Medical University, Ningde, China.
Guanwen HeNingde Clinical Medical College of Fujian Medical University, Ningde, China.
Yangbin Xu *Ningde Clinical Medical College of Fujian Medical University, Ningde, China.
Rifu Wei *Ningde Clinical Medical College of Fujian Medical University, Ningde, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Obstructive sleep apnea (OSA) significantly elevates the risk of mortality. Although physical activity is a proposed viable option in OSA treatment, its impact on mortality risk remains unclear. This study aimed to investigate the impact of physical activity on mortality in OSA patients. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) from 2015-2018 were analyzed, with physical activity levels assessed via a questionnaire. The link between physical activity and mortality risk in the OSA population was examined via logistic regression analysis, with subgroup analyses conducted. Additionally, mediation analysis was executed to elucidate the possible mediating roles of the neutrophil-percentage-to-albumin ratio (NPAR) and neutrophil-to-high-density lipoprotein cholesterol ratio (NHR). Results: A total of 4,353 OSA patients were included. Adequate physical activity was not linked to a significant decrease in all-cause mortality (ACM) [odds ratio (OR) =0.83, 95% confidence interval (CI): 0.50-1.37] nor cardiovascular mortality (OR =2.09, 95% CI: 0.78-5.64). Nevertheless, it was associated with a 72% lower risk of cancer-related death (OR =0.28, 95% CI: 0.11-0.73). Subgroup analysis indicated that the protective effect on cancer mortality was more pronounced in males (86% lower risk, OR =0.14), individuals with a body mass index (BMI) ≥30 kg/m Conclusions: Physical activity was linked to a lowered risk of cancer-related mortality in OSA patients; however, no protective effect was observed for cardiovascular mortality or ACM.

Indexed as

mortalityNational Health and Nutrition Examination Survey (NHANES)Obstructive sleep apnea (OSA)physical activity

Identifiers

PMID41229754
PMCPMC12603503

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