SynthesisFrontiers in microbiology2025
Comparison of the efficacy and safety of baloxavir versus those of oseltamivir in pediatric patients with influenza: a meta-analysis.
Synthesis in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Objective: Baloxavir is a ribonucleic acid polymerase inhibitor that effectively alleviates influenza symptoms in adults and adolescents. This meta-analysis aimed to comprehensively compare the efficacy and safety of baloxavir with those of oseltamivir in pediatric patients with influenza. Methods: A comprehensive study search was performed by encompassing multiple electronic databases, including PubMed, Web of Science, Embase, the Cochrane Library, Wan Fang, VIP, and CNKI, from database establishment to June 2025. Studies comparing the efficacy and safety of baloxavir and oseltamivir in pediatric patients with influenza were included. Results: A total of 10 studies, including 2,106 patients receiving baloxavir and 2,567 patients receiving oseltamivir, were included in the analysis. The pooled analysis indicated that baloxavir resulted in a shorter duration of symptoms and duration of fever than did oseltamivir (both Conclusion: In pediatric patients with influenza, baloxavir results in a shorter duration of symptoms and fever compared to oseltamivir, which may be attributed to their different bioavailability and half-lives. Additionally, the safety profiles of baloxavir and oseltamivir are comparable. Systematic review registration: https://www.crd.york.ac.uk/, CRD420251128843.
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