ArticleEuropean journal of case reports in internal medicine2025
Sudden-Onset Platypnea-Orthodeoxia Syndrome in a Patient with Lung Adenocarcinoma and COVID-19 Without a Patent Foramen Ovale.
Article in European journal of case reports in internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Platypnea-orthodeoxia syndrome is a rare but important cause of positional hypoxemia, typically resulting from a right-to-left shunt that may be intracardiac or intrapulmonary in origin. Case report: We present the case of a 78-year-old woman with metastatic lung adenocarcinoma and recent mild coronavirus disease 2019 (COVID-19) who developed acute-onset platypnea-orthodeoxia syndrome during hospitalization. Diagnostic workup revealed intrapulmonary shunting in the absence of pulmonary embolism or significant parenchymal lung disease. High-resolution chest computed tomography scan showed hypervascular consolidations, while bubble contrast transthoracic echocardiography confirmed delayed appearance of microbubbles in the left heart, consistent with an intrapulmonary shunt. Conclusion: This case highlights the complex interplay between tumour-induced intrapulmonary vascular abnormalities and possible COVID-19-related endothelial dysfunction in the development of platypnea-orthodeoxia syndrome. It emphasizes the need for heightened clinical suspicion and a multimodal diagnostic approach in patients with unexplained positional hypoxemia, especially in the setting of malignancy or recent viral infections. Diagnostic confirmation relies on imaging and shunt detection techniques, and management should be guided by the patient's overall prognosis and goals of care. LEARNING POINTS: Platypnea-orthodeoxia syndrome should be considered in patients with unexplained positional hypoxemia and/or dyspnoea, especially in the context of malignancy or recent viral infection.Contrast-enhanced echocardiography is key to identifying right-to-left shunts and distinguishing between intracardiac and intrapulmonary causes.Pulmonary malignancies and coronavirus disease 2019 (COVID-19) can independently or synergistically contribute to the development of platypnea-orthodeoxia syndrome through vascular remodelling and angiogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.