Evidence map›Paper›PMID 41229432›Full record

ReviewFrontiers in immunology2025

Cerebral rheumatoid vasculitis: an integrated analysis of case presentation, literature review, and prognostic stratification.

Yinghui Zhang, Xuefeng Zhai, Li Ning, Juan Yang, Liu Yang, Jian Li, Shuhong Chi, Boya Ma, Liu Lu, Zhao Li and 1 more

Abstract readReviewCase Reports
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yinghui Zhang *Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Xuefeng Zhai *Department of Pathology, General Hospital of Ningxia Medical University, Yinchuan, China.
Li NingDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Juan YangDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Liu YangDepartment of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China.
Jian LiDepartment of Radiology, General Hospital of Ningxia Medical University, Yinchuan, China.
Shuhong ChiDepartment of Rheumatology and Immunology, General Hospital of Ningxia Medical University, Yinchuan, China.
Boya MaDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Liu LuDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Zhao LiDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.
Yang XiaoDepartment of Neurology, General Hospital of Ningxia Medical University, Yinchuan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study integrated a comprehensive literature review spanning from 1951 to 2025 with a histologically confirmed case of cerebral rheumatoid vasculitis (CRV) in order to improve the management of this rare and severe complication of rheumatoid arthritis (RA). By analyzing 37 CRV cases, we observed a striking decline in mortality after the 1980s, with an odds ratio (OR) of 33.07. The combination of immunosuppressants and corticosteroids significantly enhanced treatment outcomes, showing 81.8% efficacy compared to a 63.6% mortality rate without immunosuppressants. Based on these findings, we developed the CRV diagnostic workflow to aid early detection. Our results emphasize the importance of vigilance for neurological symptoms in RA patients and highlight the need for future research to optimize treatment protocols and reduce long-term disability.

Indexed as

Arthritis, RheumatoidRheumatoid VasculitisVasculitis, Central Nervous SystemAdrenal Cortex HormonesAgedFemaleHumansImmunosuppressive AgentsMaleMiddle AgedPrognosisTreatment OutcomeAdrenal Cortex HormonesImmunosuppressive Agentsbiopsycerebral vasculitisimmunosuppressionmortalityrheumatoid arthritis

Identifiers

PMID41229432
PMCPMC12602543

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.