Evidence map›Paper›PMID 41229420›Full record

ArticleFrontiers in immunology2025

Preconditioning donors with corticosteroids improves early lung graft immunity.

Isabelle Schwartz-Cornil, Florentina Pascale, Luc Jouneau, Maxime Huriet, Jérôme Estephan, Mickael Bourge, Christophe Richard, Valérie Gelin, Claudia Bevilacqua, Julie Rivière and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Isabelle Schwartz-Cornil *Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Florentina Pascale *Université Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Luc JouneauUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Maxime HurietUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Jérôme EstephanUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Mickael BourgeCytometry/Electronic Microscopy/Light Microscopy Facility, Imagerie-Gif, Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France.
Christophe RichardUniversité Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas, France.
Valérie GelinUniversité Paris-Saclay, UVSQ, INRAE, BREED, Jouy-en-Josas, France.
Claudia BevilacquaUniversité Paris-Saclay, AgroParisTech, INRAE, GABI, Jouy-en-Josas, France.
Julie RivièreUniversité Paris-Saclay, AgroParisTech, INRAE, GABI, Jouy-en-Josas, France.
Thien-Phong Vu ManhAix Marseille University, CNRS, Inserm, CIML Centre d'Immunologie de Marseille-Luminy, Turing Center for Living Systems, Marseille, France.
Maxime DjebbourUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Antoine PremachandraUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Carla GouinUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Julien De WolfUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Chloé MimbimiDepartment of Thoracic Surgery and Lung Transplantation, Foch Hospital, Suresnes, France.
Antoine MagnanUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Antoine RouxUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Stanislas Grassin-DelyleUniversité Paris-Saclay, UVSQ, INSERM, Infection et inflammation, U1173, Département de Biotechnologie de La Santé, Montigny-le-Bretonneux, France.
Philippe DevillierUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Delphyne DescampsUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Nicolas BerthoOniris, INRAE, Bioepar, Nantes, France.
Sébastien JacqminDepartment of Anesthesiology, Foch Hospital, Suresnes, France.
Morgan Le GuenUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Edouard SageUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.
Matthieu GlorionUniversité Paris-Saclay, INRAE, UVSQ, VIM, Jouy-en-Josas, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preclinical studies have recently revealed the critical role of innate immunity in determining lung transplantation outcomes. Although the International Society for Heart and Lung Transplantation recommends high-dose corticosteroid administration to donors, this practice is inconsistently applied worldwide. Investigating its impact on the donor lung's innate immune response - an unexplored area - could provide valuable evidence to support adoption of donor preconditioning with corticosteroids, beyond their traditional administration to recipients. Method: We used a cross-circulatory pig platform that consists of a donor lung placed extracorporeally and connected to the circulation of a recipient pig whose leukocytes are fluorescently labeled. Results: Donor preconditioning - compared to recipient's treatment alone - reduced the presence of CD3 Conclusion: Our results show that the early immune status of lung grafts is improved by treating donors with corticosteroids through macrophage-targeted mechanisms. This finding provides an immunological rationale for expanding the implementation of donor preconditioning with corticosteroids.

Indexed as

Adrenal Cortex HormonesLungLung TransplantationTransplantation ConditioningAnimalsHumansImmunity, InnateMacrophages, AlveolarSwineTissue DonorsT-LymphocytesAdrenal Cortex Hormonescorticosteroidsinnate immunitylung transplantationmacrophagespreconditioningT cellstranslational research

Identifiers

PMID41229420
PMCPMC12602223

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.