ArticlePediatric endocrinology, diabetes, and metabolism2025
Impact of fig leaf extract (Ficus carica L.) on GLUT-2 expression in pancreatic b cells and hepatic cells of Wistar rats induced by streptozotocin-nicotinamide.
Article in Pediatric endocrinology, diabetes, and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Characterizing the Antihyperglycemic Activity and Underlying Mechanisms of the Aqueous Extract of the Leaves fromMolecules (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionType 2 diabetes mellitus (T2DM) is a metabolic disorder marked by hyperglycemia due to impaired carbohydrate metabolism. GLUT-2 , a key glucose transporter, regulates glucose homeostasis and insulin secretion. Medicinal plants, such as fig leaves ( Ficus carica L .), have shown potential as antidiabetic agents. AIM OF THE STUDY: To evaluate the effect of fig leaf extract on GLUT-2 expression in pancreatic β and hepatic cells, as well as fasting blood glucose (FBG) levels in Wistar rats induced with streptozotocin and nicotinamide (STZ-NA). MATERIAL AND
methodsThirty-six male Wistar rats were divided into six groups. Treatment groups received fig leaf extract at doses of 300, 500, and 700 mg/kg body weight for a period of two weeks. A glimepiride-treated group served as the positive control. Fasting blood glucose levels were measured before and after treatment. GLUT-2 expression was assessed using ELISA.
resultsFig leaf extract significantly reduced FBG levels and increased GLUT-2 expression in both pancreatic and hepatic cells. However, these effects were not statistically significant when compared to the control group. Higher extract doses showed greater trends toward glycemic improvement.
conclusionsFig leaf extract may have beneficial effects in lowering FBG and enhancing GLUT-2 expression in STZ-NA-induced diabetic rats. The data on glucose levels suggest a statistically insignificant trend toward decreased glucose levels. Although the observed improvements were not statistically significant, the trends suggest potential antidiabetic activity, particularly at higher doses. The lack of significance may be attributed to the dosage of the extract used in this study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.