Antimicrobial Efficacy of a Taurolidine-Based Antimicrobial Compound on Contaminated Surfaces Simulated in a Standardized 4-Field Test.

Benito Baldauf, Hendrik Bonnemeier, Ernest W Lau, Jana Hummel, Reinhard Vonthein, Ojan Assadian

Abstract read

In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Antimicrobial Efficacy of a Taurolidine-Based Antimicrobial Compound on Contaminated Surfaces Simulated in a Standardized 4-Field Test.Advanced healthcare materials · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benito BaldaufInstitute of life science, University of Applied Sciences Bremerhaven, 27568, Bremerhaven, Germany.ORCID https://orcid.org/0000-0001-7082-533X

Hendrik BonnemeierInstitute of life science, University of Applied Sciences Bremerhaven, 27568, Bremerhaven, Germany.ORCID https://orcid.org/0000-0002-8000-0902

Ernest W LauRoyal Victoria Hospital Belfast, Belfast, BT12 6BA, UK.ORCID https://orcid.org/0000-0003-0030-9326

Jana HummelInstitute of life science, University of Applied Sciences Bremerhaven, 27568, Bremerhaven, Germany.ORCID https://orcid.org/0000-0001-8247-6149

Reinhard VontheinIMBS, University Lübeck, 23562, Lübeck, Germany.ORCID https://orcid.org/0000-0002-0057-777X

Ojan AssadianInstitute for Skin Integrity and Infection Prevention, Human and Health Sciences, University of Huddersfield, Huddersfield, HD1 3DH, UK.ORCID https://orcid.org/0000-0003-0129-8761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Implantable medical devices, including cardiac electronic implants, joint prostheses, and breast implants, are essential to modern healthcare but remain susceptible to infection from microbial contamination during placement. Staphylococcus spp. and Candida albicans are the predominant pathogens, often causing severe complications, increased mortality, and substantial healthcare costs. With antibiotic resistance on the rise, intraoperative surface disinfection has emerged as a critical yet underutilized preventive strategy. Taurolidine, a broad-spectrum antimicrobial with a strong safety profile and no known resistance, can be applied directly to both tissues and device surfaces. To replicate intraoperative decontamination, taurolidine-saturated swabs are tested under standardized mechanical wiping using the European Norm EN 16615 "4-field test." The model reproduced short contact times and organic load conditions reflective of clinical practice, enabling assessment of both chemical and mechanical antimicrobial effects. Taurolidine achieved >5 log

Indexed as

Anti-Infective AgentsTaurineThiadiazinesCandida albicansHumansMicrobial Sensitivity TestsPseudomonas aeruginosaStaphylococcus aureusAnti-Infective AgentsTaurinetaurolidineThiadiazinesantimicrobialcardiac implantable electronic deviceimplant surface decontaminationosteosynthesis materialtaurolidine

Identifiers

PMID41229239

DOI10.1002/adhm.202503479

PMCPMC12908203

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.