ReviewInsect science2026
Neoclassical development of genetic sexing strains for insect pest and disease vector control.
Review in Insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- IAEA Coordinated Research Project on "A generic approach for the development of genetic sexing strains for Sterile Insect Technique applications"- an overview.Insect science · 2026Review
- Synthetic biology approaches to generate temperature-sensitive alleles for the Sterile Insect Technique.Insect science · 2026Review
- CRISPR/Cas9-based white pupae mutant lines in Bactrocera spp. for sterile insect technique applications.Insect science · 2026Article
- Impact of male-sterilizing doses and mating status on blood feeding rates and longevity in Aedes aegypti, Aedes albopictus, and Anopheles arabiensis females.Parasites & vectors · 2026Article
- Advances in male sex separation for the support of mosquito control programs.Frontiers in insect science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The sterile insect technique, which consists of the mass production and release of sterile insects to control populations of pests and disease vectors, has been effectively used for decades. An important component of sterile insect technique field applications is the availability of sex separation systems that reliably and economically eliminate females from mass-reared sterile insect populations destined for field release. Genetic sexing strains are important for the effectiveness and cost-efficiency of insect population control programs, including sterile insect technique. Classical approaches to generate genetic sexing strains, such as irradiation-induced chromosomal translocations, have yielded stable strains for species like the Mediterranean fruit fly, Ceratitis capitata. However, significant efforts are needed to establish genetic sexing strains using classical genetic methods, as large-scale random mutagenesis and screening are needed. We introduce here a neoclassical genetic approach, leveraging CRISPR-based gene-editing to target known genes to develop selectable genetic markers, followed by genetic rescue in a male-specific manner to speed up the development of genetic sexing strains and enhance their precision, stability, and adaptability. The integration of molecular tools, genetic markers like the white pupae and temperature-sensitive lethal, and strategies for maintaining genetic stability are discussed. We also review the challenges and opportunities in applying classical, transgenic, and neoclassical genetic approaches to improve genetic sexing strains for pest management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.