ArticleAnnals of medicine2025
Higher soluble CD8 correlates with poor prognosis in hospitalized pulmonary infection patients.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPulmonary infections pose significant challenges in accurate prognosis due to the lack of reliable biomarkers. This study aims to explore the prognostic potential of soluble CD4 (sCD4) and sCD8 for adverse outcomes in hospitalized pulmonary infection patients.
methodsThis study enrolled 112 hospitalized pulmonary infection patients and 62 healthy controls (HCs). Hospitalized patients were grouped into survivors (
resultsNon-survivors were significantly older than survivors and HCs. Compared to survivors, non-survivors presented significantly higher levels of sCD8, PCT, IL-6, CRP and CBC-derived inflammatory markers, along with significantly reduced CD3
conclusionsOur data suggest that a plasma sCD8 level above the optimal cut-off value is independently associated with poor outcomes. Elevated sCD8 may be a novel prognostic biomarker in hospitalized pulmonary infection patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.