Observational studyAnnals of medicine2025
Clinical course and outcomes of patients with anti-interferon-gamma autoantibody-associated adult-onset immunodeficiency: an observational cohort study.
Observational study in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Quantitative measurement of anti-interferon-gamma autoantibodies for routine laboratory implementation.iScience · 2026Article
- Interleukin-6 fromMicrobiology spectrum · 2026Article
- Mendelian susceptibility to mycobacterial disease: IFN-γ-driven immunity collapse underlies heterogeneous infections.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnti-interferon-gamma autoantibody (anti-IFN-γ-auto-Abs)-associated adult-onset immunodeficiency (AOID) syndrome presents with variable clinical manifestations, and long-term outcome data and natural history remain limited. MATERIALS AND
methodsThis single
resultsA total of 65 patients were recorded over an eight-year period between 2017 and 2024. The mean age of all patients was 56.4 years, and 66% were female. At initial presentation, 95 opportunistic infections were isolated from 61 patients.
conclusionThis study noted a slight shift in pathogen distribution, even though rapidly growing mycobacteria remain the most common infection. Most patients experienced non-remission, necessitating prolonged antimicrobial therapy. Our findings indicate a declining trend in antibody levels over time. Given the high rates of non-remission and the associated need for extended treatment, immunomodulatory agents should be considered, especially for non-remission patients, to potentially reduce antibody levels and the risk of infection recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.