ArticleSensors (Basel, Switzerland)2025
Smartphone-Integrated User-Friendly Electrochemical Biosensor Based on Optimized Aptamer Specific to SARS-CoV-2 S1 Protein.
Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
COVID-19, caused by SARS-CoV-2, has created unprecedented global health challenges, necessitating rapid and reliable diagnostic strategies. The spike (S) protein, particularly its S1 subunit, plays a critical role in viral entry, making it a prime biomarker for early detection. In this study, we present a disposable, low-cost, and portable electrochemical biosensor employing specifically optimized aptamers (Optimers) for SARS-CoV-2 S1 recognition. The sensing approach is based on aptamer-protein complex formation in solution, followed by immobilization onto pencil graphite electrodes (PGEs). The key parameters, including aptamer concentration, interaction time, redox probe concentration, and immobilization time, were systematically optimized by performing electrochemical measurement in redox probe solution containing ferri/ferrocyanide using differential pulse voltammetry (DPV) technique.Under optimized conditions, the biosensor achieved an ultralow detection limit of 18.80 ag/mL with a wide linear range (10
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