SynthesisNutrients2025
A Systematic Review of the Correlation Between Micronutrient Levels and Perinatal Depression.
Synthesis in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Uncovering Modifiable Contributors to Depressive Symptoms During Antidepressant Prescription Renewal: A Primary Care Case Report.Clinical case reports · 2026Article
- Relationship between pre-pregnancy body mass index and postpartum depression, and the mediation effects of cesarean delivery, low birth weight, child anomaly, and breastfeeding: a prospective birth cohort in the Japan environment and children's study.BMC pregnancy and childbirth · 2026Article
- Association between mealtime regularity and breakfast frequency with postpartum depression in first-time Japanese mothers: a cross-sectional study.BMC pregnancy and childbirth · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDepression is a significant complication of the peripartum period that can result in profound long-term detrimental implications for the affected woman, her child, and her family. It is possible that micronutrient imbalances could contribute to the development of perinatal depression through their roles in neurotransmitter synthesis and neuroendocrine and neuroimmune pathways. Micronutrient imbalances are more likely during the perinatal period due to the additional physiological demands on the body during this time. The objective of this systematic review was to review and summarise the existing evidence regarding the association between micronutrient levels and perinatal depression.
methodsMEDLINE, EMBASE, PsycINFO, CINAHL, Scopus, and Web of Science were searched for studies examining blood levels of micronutrients and assessment of depression within the peripartum period using validated rating tools.
resultsA total of 58 studies met the eligibility criteria and were included in this review. Of these, 31 studies reported a significant inverse association between perinatal depression and at least one of the following: vitamin D, iron status, vitamin B12, folate, or zinc. Vitamin D was the most frequently investigated nutrient, examined in 28 of the 58 articles. The remaining 27 did not demonstrate a significant association.
conclusionThis review found that vitamin D deficiency has the greatest evidence of an association with perinatal depression. The evidence for other micronutrients is mixed, inconclusive, or limited. Further research is required to determine the significance of these micronutrients in the development of perinatal depression.
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