ArticleNutrients2025
Associations of Composite Dietary Antioxidant Index and Dietary Inflammation Index with Cognitive Dysfunction in Older Chinese Adults: Results from China Health and Nutrition Survey in 2018.
Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Sex-Specific Associations of Triglyceride-Glucose Index and a Body Shape Index with Cardiometabolic Multimorbidity Risk: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Associations of Dietary Antioxidant and Phytochemical Indices with Cognitive Function: Mediating Roles of Basal Metabolic Rate and Systemic Inflammation.Antioxidants (Basel, Switzerland) · 2026Article
- Antioxidant vitamin index and risk of age-related macular degeneration: multicenter validation and clinical translation.npj aging · 2026Article
- From nutrient-based to food-based assessment: the evolution of inflammatory indices and their significance for metabolic syndrome and type 3 diabetes mellitus.Frontiers in nutrition · 2026Review
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8 authors.
Funding
Abstract
backgroundPrevious studies have shown that a diet with inflammatory and antioxidant properties can alter the risk of cognitive impairment. There are few studies using a large sample of the Chinese population. The specific relationship between inflammation, an antioxidant diet, and cognitive impairment remains unclear, and the potential impact of metabolic disorders remains to be determined.
methodsThis is a cross-sectional study, with data from the China Health and Nutrition Survey (CHNS) in 2018. Individual and combined effects of the dietary inflammation index (DII) and composite dietary antioxidant index (CDAI) on cognitive impairment were assessed by binary logistic regression models. Nonlinear correlations and the inflection point were explored using restricted cubic splines (RCSs), and the mediation effects of triglyceride glucose-body mass index (TyG-BMI) were explored in greater depth using causal mediation analysis.
resultsAn increased CDAI was associated with a significantly decreased risk of cognitive impairment, at 0.68 (95%CI: 0.499-0.928). Contrary to this, the DII was positively associated with the risk of cognitive impairment, at 1.289 (95%CI: 1.03-1.613). The joint effects of the DII and CDAI indicated the minimal hazard effects on the risk of cognitive (0.787 (95%CI: 0.622-0.995)) impairment in subjects with low_DII + high_CDAI when compared with those with high_DII + low_CDAI. Furthermore, a significant nonlinear relationship was found between the CDAI and the risk of cognitive impairment, exhibiting an "L"-shaped curve (
conclusionsFindings revealed that the CDAI could mitigate the adverse consequences of the DII on cognitive decline, which offers new insights into preventing early cognitive impairment through dietary intervention.
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