Evidence map›Paper›PMID 41228410›Full record

ArticleNutrients2025

ROS-Mediated Nematocidal Activity and Reproductive Toxicity of Herbal Extracts in

Anna Hu, Qinghao Meng, Zifei Liu, Yuxuan Wu, Robert P Borris, Hyun-Min Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna HuNatural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China.ORCID 0009-0006-0451-8116
Qinghao MengSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Zifei LiuNatural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China.ORCID 0000-0003-1747-2568
Yuxuan WuNatural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China.
Robert P BorrisSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
Hyun-Min KimNatural and Applied Sciences, Duke Kunshan University, Kunshan 215316, China.ORCID 0000-0003-4610-3606

Funding

CSRD VA 1Kunshan Shuangchuang grant KSSC202202060
6 · The paper itself

Abstract

BACKGROUND/

objectivesTraditional medicinal plants are a rich source of phytochemicals with diverse biological effects, yet their safety and mechanistic impact on reproductive health remain underexplored. In this study, we investigated the effects of

methodsSynchronized young adult worms were exposed to each extract, and survival and reproductive parameters were statistically analyzed using two-tailed Mann-Whitney tests.

resultsThrough LC-MS analysis, we identified that all three extracts shared 78 compounds, mainly including phenolic acids, flavonoids, and terpenoids. Our findings indicate that reactive oxygen species generation is a major driver of nematocidal and fertility-reducing effects, while modulation of DNA damage response pathways further contributes to germline defects.

conclusionsTaken together, these results demonstrate that exposure to the extracts significantly (

Indexed as

Antinematodal AgentsCaenorhabditis elegansPlant ExtractsReactive Oxygen SpeciesAnimalsDNA DamageFemaleFertilityMalePlants, MedicinalReproductionAntinematodal AgentsPlant ExtractsReactive Oxygen SpeciesDNA repairgermline developmentJuniperus oblongameiosisRuscus hyrcanusStachys lavandulifolia

Identifiers

PMID41228410
PMCPMC12608140

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.