Evidence map›Paper›PMID 41228378›Full record

ArticleCancers2025

High Implementation Adherence to Lenalidomide in Multiple Myeloma.

Irina Amitai, Hila Magen, Avi Leader, Antoine Pironet, Eric Tousset, Alon Rozental, Sabina De Geest, Iuliana Vaxman, Pia Raanani, Arnon Nagler

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Irina AmitaiDivision of Hematology, Chaim Sheba Medical Center, Ramat-Gan 5262000, Israel.
Hila MagenDivision of Hematology, Chaim Sheba Medical Center, Ramat-Gan 5262000, Israel.ORCID 0000-0002-3990-394X
Avi LeaderThe Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Antoine PironetAARDEX Group, 4432 Ans, Belgium.ORCID 0000-0002-1610-3050
Eric ToussetAARDEX Group, 4432 Ans, Belgium.
Alon RozentalThe Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Sabina De GeestInstitute of Nursing Science, Department Public Health, University of Basel, 4056 Basel, Switzerland.ORCID 0000-0001-6596-7237
Iuliana VaxmanThe Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.
Pia RaananiThe Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel.ORCID 0000-0001-9973-639X
Arnon NaglerDivision of Hematology, Chaim Sheba Medical Center, Ramat-Gan 5262000, Israel.ORCID 0000-0002-0763-1265

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

background and purposeAdherence to oral anticancer therapy correlates with outcome. Lenalidomide (LEN) is an oral mainstay treatment for multiple myeloma (MM), administered in 21-day/7-day (on/off) cycles. Data on LEN adherence is limited. Electronic monitoring (EM) represents the most reliable adherence assessment method. EXPERIMENTAL APPROACH: We conducted a prospective observational study using electronic medication event monitoring (MEMS KEY

resultsEighty-five patients were included. Median age was 68 years, 66% received LEN as a second-line treatment, 75% of patients perfectly adhered to the recommended 21/7-day on/off cycle. Median implementation adherence was 100%. Only 4% of patients had a proportion of doses taken below 90%. All doses were taken by 51% of patients, while 9% missed ≥4 doses. Among the 13 predictors investigated, only age under 80 and participation in a support group were statistically significant.

conclusionsthis novel assessment of LEN adherence in MM patients demonstrated high implementation adherence and cycle duration compliance.

Indexed as

adherencecompliancelenalidomidemultiple myelomaoral anti cancer medications

Identifiers

PMID41228378
PMCPMC12606733

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.