ArticleCancers2025
Threshold-Based Overlap of Breast Cancer High-Risk Classification Using Family History, Polygenic Risk Scores, and Traditional Risk Models in 180,398 Women.
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Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
119 authors.
Peh Joo HoGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.ORCID 0000-0002-3017-4023
Christine Kim Yan LooGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.ORCID 0009-0007-3689-3970
Ryan Jak Yang LimGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.
Meng Huang GohGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.
Mustapha AbubakarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.ORCID 0000-0003-3728-6535
Thomas U AhearnDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.ORCID 0000-0003-0771-7752
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.ORCID 0000-0002-4226-6435
Natalia N AntonenkovaN.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040 Minsk, Belarus.
Kristan J AronsonDepartment of Public Health Sciences, Sinclair Cancer Research Institute, Queen's University, Kingston, ON K7L 3N6, Canada.
Annelie AugustinssonOncology, Department of Clinical Sciences in Lund, Lund University, 221 85 Lund, Sweden.ORCID 0000-0003-3415-0536
Sabine BehrensDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-9714-104X
Clara BodelonDepartment of Population Science, American Cancer Society, Atlanta, GA 30303, USA.ORCID 0000-0002-6578-2678
Natalia V BogdanovaN.N. Alexandrov Research Institute of Oncology and Medical Radiology, 223040 Minsk, Belarus.ORCID 0000-0002-9736-4593
Manjeet K BollaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.
Kristen D BrantleyDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0003-0084-4775
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-6129-1572
Helen ByersDivision of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.
Nicola J CampDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.ORCID 0000-0002-4788-1998
Jose E CastelaoOncology and Genetics Unit, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS) Foundation, Complejo Hospitalario Universitario de Santiago, SERGAS, 36312 Vigo, Spain.
Melissa H CessnaIntermountain Healthcare, Salt Lake City, UT 84143, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Georgia Chenevix-TrenchCancer Research Program, QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Ji-Yeob ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul 03080, Republic of Korea.
Sarah V ColonnaDepartment of Internal Medicine and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Kamila CzeneDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-3233-5695
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Francoise DerouaneLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000 Leuven, Belgium.
Thilo DörkGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-9458-0282
A Heather EliassenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-3961-6609
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0002-7247-282X
Mikael ErikssonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-8135-4270
D Gareth EvansDivision of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0002-8482-5784
Olivia FletcherThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.ORCID 0000-0001-9387-7116
Lin FritschiSchool of Population Health, Curtin University, Perth, WA 6102, Australia.ORCID 0000-0002-7692-3560
Manuela Gago-DominguezCancer Genetics and Epidemiology Group, Genomic Medicine Group, Fundación Instituto de Investigación Sanitaria de Santiago de Compostela (FIDIS), Complejo Hospitalario Universitario de Santiago, Servicio Gallego de Salud (SERGAS), 15706 Santiago de Compostela, Spain.
Jeanine M GenkingerDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.ORCID 0000-0002-8438-0412
Willemina R R Geurts-GieleDepartment of Clinical Genetics, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada.
Per HallDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-5640-9126
Ute HamannMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0001-6705-7624
Cecilia Y S HoDepartment of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, China.ORCID 0000-0001-6870-3587
Weang-Kee HoSchool of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor 43500, Malaysia.
Maartje J HooningDepartment of Clinical Genetics, Erasmus University Medical Center, 3015 CN Rotterdam, The Netherlands.ORCID 0000-0001-6763-0857
Reiner HoppeDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, 70376 Stuttgart, Germany.
Anthony HowellDivision of Cancer Sciences, University of Manchester, Manchester M13 9PL, UK.
Keith HumphreysDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0002-7458-8252
Hidemi ItoDivision of Cancer Information and Control, Aichi Cancer Center Research Institute, Nagoya 464-8681, Japan.ORCID 0000-0002-8023-4581
Motoki IwasakiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo 104-0045, Japan.
Anna JakubowskaIndependent Laboratory of Molecular Biology and Genetic Diagnostics, Pomeranian Medical University, 171-252 Szczecin, Poland.ORCID 0000-0002-5650-0501
Helena JernströmOncology, Department of Clinical Sciences in Lund, Lund University, 221 85 Lund, Sweden.ORCID 0000-0002-2301-5147
Esther M JohnDepartment of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, CA 94305, USA.
Nichola JohnsonThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London SW7 3RP, UK.ORCID 0000-0002-8230-5662
Daehee KangCancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Sung-Won KimDepartment of Surgery, Daerim Saint Mary's Hospital, Seoul 07442, Republic of Korea.ORCID 0000-0001-5687-1380
Cari M KitaharaRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0001-6416-4432
Yon-Dschun KoDepartment of Internal Medicine, Johanniter GmbH Bonn, Johanniter Krankenhaus, 53177 Bonn, Germany.
Peter KraftDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20850, USA.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Hong Kong, China.ORCID 0000-0002-6968-9489
Diether LambrechtsLaboratory for Translational Genetics, Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
Susanna LarssonInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-0118-0341
Shuai LiCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.ORCID 0000-0002-8696-8594
Annika LindblomDepartment of Molecular Medicine and Surgery, Karolinska Institutet, 171 76 Stockholm, Sweden.ORCID 0000-0001-7675-7569
Martha LinetRadiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
Jolanta LissowskaDepartment of Cancer Epidemiology and Prevention, M. Sklodowska-Curie National Research Oncology Institute, 02-034 Warsaw, Poland.ORCID 0000-0003-2695-5799
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.ORCID 0000-0003-0550-4657
Robert J MacInnisCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0002-1627-5047
Arto MannermaaTranslational Cancer Research Area, University of Eastern Finland, 70210 Kuopio, Finland.
Siranoush ManoukianUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, 20133 Milan, Italy.
Sara MargolinDepartment of Oncology, Södersjukhuset, 118 83 Stockholm, Sweden.
Keitaro MatsuoDivision of Cancer Epidemiology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan.ORCID 0000-0003-1761-6314
Kyriaki MichailidouCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.ORCID 0000-0001-7065-1237
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.
Nur Aishah Mohd TaibDepartment of Surgery, Faculty of Medicine, UM Cancer Research Institute, University of Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0001-8419-0478
Kenneth R MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester M13 9PL, UK.
Rachel A MurphySchool of Population and Public Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.ORCID 0000-0003-4383-5641
William G NewmanDivision of Evolution, Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester M13 9PT, UK.ORCID 0000-0002-6382-4678
Katie M O'BrienEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, Durham, NC 27709, USA.
Nadia ObiInstitute for Occupational and Maritime Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0000-0002-0903-9142
Olufunmilayo I OlopadeCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, IL 60637, USA.
Mihalis I PanayiotidisDepartment of Cancer Genetics, Therapeutics and Ultrastructural Pathology, The Cyprus Institute of Neurology & Genetics, Nicosia 2371, Cyprus.ORCID 0000-0002-1450-3552
Sue K ParkCancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.ORCID 0000-0001-5002-9707
Tjoung-Won Park-SimonGynaecology Research Unit, Hannover Medical School, 30625 Hannover, Germany.ORCID 0000-0002-2863-3040
Alpa V PatelDepartment of Population Science, American Cancer Society, Atlanta, GA 30303, USA.
Paolo PeterlongoLaboratory of Hematology-Oncology, European Institute of Oncology IRCCS, 20133 Milan, Italy.ORCID 0000-0001-6951-6855
Dijana Plaseska-KaranfilskaResearch Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts (MASA), 1000 Skopje, North Macedonia.ORCID 0000-0001-8877-2416
Katri PylkäsLaboratory of Cancer Genetics and Tumor Biology, Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, 90220 Oulu, Finland.ORCID 0000-0002-2449-0521
Muhammad U RashidMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.ORCID 0000-0002-7684-3122
Gad RennertFaculty of Medicine, Technion-Israel Institute of Technology and Association for Promotion of Research in Precision Medicine, Haifa 35254, Israel.ORCID 0000-0002-8512-068X
Juan RodriguezDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 65 Stockholm, Sweden.ORCID 0000-0001-9803-8346
Emmanouil SaloustrosDivision of Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, 411 10 Larissa, Greece.
Dale P SandlerEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, Durham, NC 27709, USA.ORCID 0000-0002-6776-0018
Elinor J SawyerSchool of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, King's College London, London SE1 1UL, UK.ORCID 0000-0001-8285-4111
Christopher G ScottDepartment of Quantitative Health Sciences, Division of Clinical Trials and Biostatistics, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-1340-0647
Shamim ShahiDepartment of Population Science, American Cancer Society, Atlanta, GA 30303, USA.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.ORCID 0000-0002-0711-8314
Katerina ShulmanClalit Regional Oncology Unit, Haifa and Western Galilee District, Haifa 3436212, Israel.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Qubec-Universit Laval Research Center, Quebec City, QC G1V 4G2, Canada.ORCID 0000-0001-6906-3390
Melissa C SoutheyPrecision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.
Jennifer StoneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC 3010, Australia.ORCID 0000-0001-5077-0124
Jack A TaylorEpidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, Durham, NC 27709, USA.ORCID 0000-0001-5303-6398
Soo-Hwang TeoCancer Research Malaysia, Subang Jaya, Selangor 47500, Malaysia.ORCID 0000-0002-0444-590X
Lauren R TerasDepartment of Population Science, American Cancer Society, Atlanta, GA 30303, USA.ORCID 0000-0003-2419-8536
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
Diana TorresMolecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Celine M VachonDepartment of Quantitative Health Sciences, Division of Epidemiology, Mayo Clinic, Rochester, MN 55905, USA.
Maxime Van HoudtDepartment of Gynecological Oncology, University Hospitals of Leuven, 3000 Leuven, Belgium.ORCID 0000-0002-4639-6894
Jelle VerhoevenLeuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000 Leuven, Belgium.ORCID 0000-0003-1534-3340
Clarice R WeinbergBiostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, Durham, NC 27709, USA.ORCID 0000-0002-7713-8556
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0001-7387-6845
Taiki YamajiDivision of Epidemiology, National Cancer Center Institute for Cancer Control, Tokyo 104-0045, Japan.
Cheng Har YipDepartment of Surgery, Faculty of Medicine, UM Cancer Research Institute, University of Malaya, Kuala Lumpur 50603, Malaysia.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.ORCID 0000-0003-1226-070X
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.ORCID 0000-0001-5726-9965
Jingmei LiGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.ORCID 0000-0001-8587-7511
On Behalf Of The Abctb InvestigatorsAustralian Breast Cancer Tissue Bank, Westmead Institute for Medical Research, University of Sydney, Sydney, NSW 2145, Australia.
kConFab InvestigatorsResearch Department, Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia.
MyBrCa InvestigatorsSchool of Mathematical Sciences, Faculty of Science and Engineering, University of Nottingham Malaysia, Semenyih, Selangor 43500, Malaysia.
Sgbcc InvestigatorsGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore 138672, Singapore.
Funding
Core-001U01CA164920 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Irene Andrulis, Sarah Violet Colonna · 2018 to 2026
$17.0MBreast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7MAgency for Science, Technology and ResearchNCI NIH HHS U01 CA164920NCI NIH HHS UM1 CA164920
Abstract
PubMed holds no abstract for this paper.
Indexed as
BRCA1BRCA2breast cancerductal carcinoma in situ (DCIS)Gail modelpolygenic risk score (PRS)risk-based screeningrisk stratification
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