Evidence map›Paper›PMID 41228336›Full record

ArticleCancers2025

Tumor Genomics, Metastatic Patterns, and Prognosis in Leiomyosarcoma: A Single-Center Retrospective Cohort Study.

Hayes Pearce, Yu-Cherng Chang, Sarah Wishnek Metalonis, Brandon Edward Rose, Emily E Jonczak, Ty Subhawong, Gina D'Amato, Julie Grossman, Patricia Castillo, Marilyn Huang and 5 more

Abstract read
In one paragraph

Article in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hayes PearceLeonard M. Miller School of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0009-0006-2755-8807
Yu-Cherng ChangDepartment of Radiology, Jackson Memorial Hospital, Miami, FL 33136, USA.
Sarah Wishnek MetalonisDivision of Biostatistics, Department of Public Health, University of Miami, Miami, FL 33136, USA.
Brandon Edward RoseDepartment of Medicine, University of Miami, Miami, FL 33136, USA.
Emily E JonczakDivision of Medical Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA.
Ty SubhawongSylvester Comprehensive Cancer Center, Miami, FL 33136, USA.ORCID 0000-0003-0943-1168
Gina D'AmatoDivision of Medical Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-6981-7527
Julie GrossmanSylvester Comprehensive Cancer Center, Miami, FL 33136, USA.ORCID 0000-0001-9323-5228
Patricia CastilloSylvester Comprehensive Cancer Center, Miami, FL 33136, USA.
Marilyn HuangDivision of Gynecologic Oncology, UVA Health, Charlottesville, VA 22903, USA.
Marco MagistriCaris Life Sciences, 4610 South 44th Place, Phoenix, AZ 85040, USA.
Francis HornicekDepartment of Orthopedic Surgery, University of Miami, Miami, FL 33136, USA.ORCID 0000-0002-6916-8042
Andrew E RosenbergDepartment of Pathology & Laboratory Medicine, University of Miami, Miami, FL 33136, USA.
Jonathan C TrentDivision of Medical Oncology, Department of Medicine, University of Miami, Miami, FL 33136, USA.ORCID 0000-0001-6169-5238
Francesco AlessandrinoSylvester Comprehensive Cancer Center, Miami, FL 33136, USA.

Funding

Miami Clinical and Translational Science InstituteUM1TR004556 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Olveen Carrasquillo, ERIN N KOBETZ · 2023 to 2026
$16.0M
NCATS NIH HHS UM1 TR004556
6 · The paper itself

Abstract

BACKGROUND/

objectivesThe prognostic associations of tumor genomics and metastatic patterns remain incompletely defined in leiomyosarcoma (LMS). We investigated the association between tumor mutations, sites of metastasis, and survival in patients with LMS.

methodsThis single-center retrospective cohort study evaluated 110 patients with biopsy-proven LMS who underwent genomic testing between January 2009 and May 2023. Associations between tumor mutations, metastatic sites, and uterine vs. non-uterine LMS were assessed using χ

resultsThe study included 110 subjects (F/M: 81/29; median age, 57 years; 25/110 with metastatic disease). Overall, the most common mutations were in

conclusionsOur study identifies differences in metastatic patterns between uterine and non-uterine LMS and highlights the adverse prognostic association of

Indexed as

biomarkersgenomic profilingleiomyosarcomametastatic patternsnext-generation sequencingprecision oncologysoft tissue sarcoma

Identifiers

PMID41228336
PMCPMC12607597

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.