Evidence map›Paper›PMID 41228305›Full record

ReviewCancers2025

Causes of Childhood Cancer: A Literature Review (2014-2021)-Part 3: Environmental and Occupational Factors.

Rebecca T Emeny, Mary E Butow, Linda Titus, Angela M Ricci, Pamela J Bagley, Heather B Blunt, Alexandra Morgan, Jennifer A Alford-Teaster, Raymond R Walston, Judy R Rees

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebecca T EmenyDepartment of Internal Medicine, Division of Molecular Medicine, UNM Comprehensive Cancer Center, Cancer Control & Population Sciences Research Program, University of New Mexico Health Sciences, Albuquerque, NM 87131, USA.ORCID 0000-0002-8780-5439
Mary E ButowNew Hampshire Department of Health and Human Services, Concord, NH 03302, USA.
Linda TitusDepartment of Pediatrics, Geisel School of Medicine at Dartmouth, Dartmouth Cancer Center, Hanover, NH 03755, USA.ORCID 0000-0002-0599-3924
Angela M RicciDepartment of Pediatrics, Division of Pediatric Hematology-Oncology, Dartmouth Health Children's, Lebanon, NH 03756, USA.ORCID 0000-0003-3507-9946
Pamela J BagleyBiomedical Libraries, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.ORCID 0000-0002-1214-7814
Heather B BluntBiomedical Libraries, Geisel School of Medicine at Dartmouth, Hanover, NH 03755, USA.
Alexandra MorganDepartment of Obstetrics and Gynecology, Dartmouth Health, Lebanon, NH 03756, USA.ORCID 0000-0001-8531-5762
Jennifer A Alford-TeasterNew London Hospital Association, New London, NH 03257, USA.ORCID 0000-0002-2600-446X
Raymond R WalstonDepartment of Pediatric Hematology Oncology, Children's Hospital Colorado, Aurora, CO 80045, USA.
Judy R ReesDepartment of Epidemiology, Geisel School of Medicine at Dartmouth, Dartmouth Cancer Center, Hanover, NH 03755, USA.

Funding

New Hampshire Drinking Water and Ground Water Trust Fund N/A
6 · The paper itself

Abstract

purposeTo achieve a better understanding of the environmental factors that contribute to childhood cancers, so as to inform future prevention efforts.

methodsWe conducted a comprehensive review of epidemiological studies on environmental risk factors and childhood cancer, which was published between January 2014 and March 2021. Potential exposure sources presented in this review include air pollution, radiation, and parental occupational exposures. We considered exposures during childhood and parental exposures occurring before the child's conception and during pregnancy in relation to all types of childhood cancer.

resultsAggregated evidence is strong for associations between leukemia and parental/child exposure to traffic pollution, indoor paints, residential pesticides, and parental occupational/nonoccupational exposure to benzene. Evidence is also strong for associations between brain cancer and residential pesticides and parental occupational exposure to agricultural pesticides. Evidence of associations between leukemia and ionizing radiation from radon and nuclear power plants remains mixed, as does evidence of a link between electromagnetic fields (EMFs) and childhood leukemia.

conclusionsClear associations have been demonstrated between childhood cancer and environmental factors, including parent/child exposure to traffic pollution, occupational/nonoccupational benzene, indoor paints, residential pesticides, and parental occupational exposure to agricultural pesticides. These associations can be used to inform further study of interventions and public health campaigns to reduce risk.

Indexed as

environmental risk factorsepidemiologyetiologyoccupational risk factorspediatric cancer

Identifiers

PMID41228305
PMCPMC12609540

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.