Evidence map›Paper›PMID 41228226›Full record

ReviewCancers2025

Comparative Effectiveness of Interventions to Treat Cancer Treatment-Related Cognitive Impairment in Adult Cancer Survivors Following Systemic Therapy: A Systematic Review with Network Meta-Analyses.

Dianna M Wolfe, Candyce Hamel, Jason Berard, Areti Angeliki Veroniki, Becky Skidmore, Salmaan Kanji, Kiran Rabheru, Sharon F McGee, Leta Forbes, Igor de Lima Machado and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dianna M WolfeMethodological and Implementation Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0003-1807-6647
Candyce HamelMethodological and Implementation Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0002-5871-2137
Jason BerardNeuroscience Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Areti Angeliki VeronikiCenter for Evidence Synthesis in Health, Department of Health Services, Policy, and Practice, School of Public Health, Brown University, Providence, RI 02912, USA.
Becky SkidmoreIndependent Researcher, Ottawa, ON K1H 8L6, Canada.
Salmaan KanjiMethodological and Implementation Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Kiran RabheruDepartment of Psychiatry, University of Ottawa, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0003-0467-3715
Sharon F McGeeDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Leta ForbesOntario Health (Cancer Care Ontario), Toronto, ON M5G 2L3, Canada.
Igor de Lima MachadoDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Michelle LiuCancer Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Deanna SaundersCancer Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Lisa VandermeerCancer Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.
Mark ClemonsDivision of Medical Oncology, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0001-9392-8219
Brian HuttonMethodological and Implementation Research Program, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, ON K1H 8L6, Canada.ORCID 0000-0001-5662-8647

Funding

CIHR 183699
6 · The paper itself

Abstract

backgroundCancer treatment-related cognitive impairment (CTRCI) is a frequent and persistent consequence of systemic cancer therapy, adversely affecting quality of life and independence among cancer survivors.

methodsTo clarify the relative effectiveness of available treatments, we conducted a systematic review and network meta-analyses of randomized controlled trials evaluating psychological, pharmacological, and other interventions for established CTRCI in adult survivors of non-central nervous system cancers. Eligible trials reported objective outcomes in one or more of eight cognitive domains, including learning, memory, processing speed, word generation, cognitive flexibility, attention, working memory, and abstraction.

resultsEighteen studies met inclusion criteria, with 14 trials (

conclusionsWhile findings suggest that structured multimodal group interventions may represent the most promising strategy for CTRCI, CoE was low, and additional rigorous, standardized trials are required.

Indexed as

cancer survivorshipcancer-treatment-related cognitive impairmentcognitive rehabilitationnetwork meta-analysissystematic review

Identifiers

PMID41228226
PMCPMC12609492

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.