Zinc Chelates from Low-Molecular-Weight Donkey-Hide Gelatin Peptides: Preparation, Characterization, and Evaluation of In Vitro Antioxidant Activity.

Wenxuan Han, Lili Yang, Yujie Fan, Yanyan Lv, Xiao Li, Yuhang Li, Siyu Li, Rong Liang

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Food-Derived Zinc-Chelating Peptides: Coordination Chemistry, Intestinal Transport, and Nutritional Functionality.Nutrients · 2026
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5 · Who and what money

Authors and funding

8 authors.

Wenxuan HanShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Lili YangShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Yujie FanShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Yanyan LvShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Xiao LiShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Yuhang LiShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Siyu LiShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Rong LiangShandong Key Laboratory of Applied Technology for Protein and Peptide Drugs, School of Pharmaceutical Sciences and Food Engineering, Liaocheng University, Liaocheng 252059, China.

Funding

Science and Technology Smes Innovation Ability Improvement Project of Shandong Province 2023TSGC0386, 2023TSGC0362Shandong Provincial College Students' Innovation and Entrepreneurship Training Program 202410447028

6 · The paper itself

Abstract

This study synthesized a low-molecular-weight donkey-hide gelatin peptide-zinc chelate (LMW DHGP-Zn) using peptides derived from donkey-hide gelatin. Under optimized conditions (zinc concentration of 32 mg/mL, peptide-to-zinc mass ratio of 8:1, pH 6.5, 60 °C, 70 min), a maximum chelation rate of 41.34% ± 0.23% was achieved. Comprehensive characterization via scanning electron microscopy, ultraviolet-visible spectroscopy, fluorescence spectroscopy, zeta potential, particle size, Fourier transform infrared spectroscopy, and circular dichroism confirmed substantial structural and physicochemical alterations post-chelation. After chelation, the surface charge is neutralized, and the distribution of particles is more even. Furthermore, analysis indicated an elevated content of acidic amino acids (glutamic acid and aspartic acid), and spectroscopic data confirmed the coordination of zinc ions with amino and carboxyl groups on the peptide. Consequently, the LMW DHGP-Zn chelate demonstrated significantly enhanced ABTS radical cation scavenging activity. These results provide a scientific foundation for its potential application as a natural antioxidant in the food, cosmetic, and pharmaceutical industries.

Indexed as

antioxidant activitylow-molecule-weight donkey-hide gelatin peptidepeptide–zinc chelatespreparation process optimizationstructural characterization

Identifiers

PMID41227643

DOI10.3390/foods14213671

PMCPMC12607457

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.