Evidence map›Paper›PMID 41227389›Full record

ArticleCells2025

Gap Junctional Communication Required for the Establishment of Long-Term Robust Ca

Jasmin Kormann, Eike Cöllen, Ayla Aksoy-Aksel, Jana Schneider, Yaroslav Tanaskov, Kevin Wulkesch, Marcel Leist, Udo Kraushaar

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jasmin KormannNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Eike CöllenDoerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, 78457 Konstanz, Germany.ORCID 0009-0001-7670-8078
Ayla Aksoy-AkselNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Jana SchneiderNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.
Yaroslav TanaskovDoerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, 78457 Konstanz, Germany.ORCID 0009-0009-5069-0023
Kevin WulkeschDoerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, 78457 Konstanz, Germany.
Marcel LeistDoerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, 78457 Konstanz, Germany.ORCID 0000-0002-3778-8693
Udo KraushaarNMI Natural and Medical Sciences Institute at the University of Tübingen, 72770 Reutlingen, Germany.ORCID 0000-0002-4660-1093

Funding

European Union's Horizon 2020 101057014European Union's Horizon 2020 964518European Union's Horizon 2020 964537German Federal Ministry of Education and Research 16LW0147German Federal Ministry of Education and Research 16LW0575Kooperatives Promotionskolleg (KPK) InViTe2 Sigmaringen/Konstanz n.a.
6 · The paper itself

Abstract

Synchronized oscillatory fluctuations in intracellular calcium concentration across extended neuronal networks represent a functional indicator of connectivity and signal coordination. In this study, a model of human immature neurons (differentiated from LUHMES precursors) has been used to establish a robust protocol for generating reproducible intracellular Ca

Indexed as

CalciumCalcium SignalingCell CommunicationCell Culture TechniquesGap JunctionsNeuronsSpheroids, CellularConnexin 43HumansCalciumConnexin 43Ca2+ oscillationsgap junctionshuman dopaminergic neuronal-like cellsnetwork synchronization

Identifiers

PMID41227389
PMCPMC12607754

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.