Evidence map›Paper›PMID 41227387›Full record

ArticleCells2025

Butyrate Enhances Antimicrobial Defence in Chicken Macrophages Through Reactive Oxygen Species Generation and Autophagy Activation.

James R G Adams, Faisal R Anjum, Jai W Mehat, Roberto M La Ragione, Shahriar Behboudi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. TheCells · 2026
    Article
  2. Effects ofAnimals : an open access journal from MDPI · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James R G AdamsDiscipline of Veterinary Clinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7AL, UK.ORCID 0000-0002-3415-2999
Faisal R AnjumBristol Veterinary School, University of Bristol, Langford BS40 5DU, UK.
Jai W MehatDiscipline of Microbes, Infection and Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.ORCID 0000-0002-9563-6348
Roberto M La RagioneDiscipline of Microbes, Infection and Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK.
Shahriar BehboudiThe Pirbright Institute, Pirbright, Woking GU24 0NE, UK.

Funding

Biotechnology and Biological Sciences Research Council BB/S01506X/1Biotechnology and Biological Sciences Research Council BBS/E/I/00007030Biotechnology and Biological Sciences Research Council BB/T020954/1Biotechnology and Biological Sciences Research Council BB/T020954/2The British Egg Marketing Research and Education Trust, United Kingdom Not provided
6 · The paper itself

Abstract

Sodium butyrate has been documented to support gut function and help control pathogens in the gastrointestinal tract. However, the precise mechanisms of dietary sodium butyrate's control over enteric pathogens in chickens remain unclear. Our study demonstrated that priming chicken bone marrow-derived macrophages (BMDMs) or the HD11 cell line with 1 mM sodium butyrate significantly enhanced their antimicrobial capacity against key bacterial pathogens (

Indexed as

Anti-Infective AgentsAutophagyButyric AcidMacrophagesReactive Oxygen SpeciesAnimalsCell LineChickensTOR Serine-Threonine KinasesAnti-Infective AgentsButyric AcidReactive Oxygen SpeciesTOR Serine-Threonine KinasesAPECautophagychickenmacrophagesprimingROSsodium butyrate

Identifiers

PMID41227387
PMCPMC12608662

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.