Evidence map›Paper›PMID 41227359›Full record

ArticleCells2025

Evaluation of Rat Testicular Cell Populations in Experimental Condition of Diabetes Induced in Early Postnatal Life.

Ekaterina Pavlova, Rosen Ivanov, Desislava Abadjieva, Yordanka Gluhcheva, Emilia Petrova, Ivelin Vladov, Emilia Lakova, Nina Atanassova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ekaterina PavlovaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.ORCID 0000-0002-8821-653X
Rosen IvanovInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.ORCID 0009-0006-5252-7615
Desislava AbadjievaInstitute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences "Acad. Kiril Bratanov", 1113 Sofia, Bulgaria.ORCID 0000-0002-7869-2022
Yordanka GluhchevaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.
Emilia PetrovaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.ORCID 0000-0001-6971-1183
Ivelin VladovInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.ORCID 0000-0003-1032-1249
Emilia LakovaDepartment of Physiology and Pathophysiology, Medical University of Pleven, 5800 Pleven, Bulgaria.
Nina AtanassovaInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., bl.25, 1113 Sofia, Bulgaria.ORCID 0000-0002-9032-3588

Funding

Bulgarian National Science Fund KP-06-N71/7 from 08.12.2024
6 · The paper itself

Abstract

Diabetes mellitus (DM) causes male infertility through the suppression of spermatogenesis and testosterone biosynthesis. The impact of DM on male reproduction has mainly been investigated in adulthood, therefore we aimed to study the developmental effects of DM, induced in early life, on testicular cell population and fertility. Neonatal (NDM) and prepubertal DM (PDM) were induced in immature rats by streptozotocin administration on day 1 or day 10, respectively. Germ (GCs) and somatic cells (Sertoli-SCs and Leydig cells-LCs) were counted in pubertal (25 day) and post-pubertal (45 day) rats in tandem with the measurement of serum testosterone levels and the protein expression of androgen receptor. Glucose levels were higher in PDM than in NDM. Incomplete spermatogenesis and reduced GC number were found in PDM but not in NDM. LC number, testosterone, and luteinizing hormone (LH) levels were differently altered by both types of DM with a pronounced negative impact of PDM. Protein expression of androgen receptor in SCs was altered only in PDM. Reduced sperm concentration and motility was found in both groups. Thus, our results provide new insights into different mechanisms of action of PDM and NDM on developing germ cells that involved disturbances in androgen production by Leydig cells and androgen action in Sertoli cells.

Indexed as

Diabetes Mellitus, ExperimentalTestisAnimalsAnimals, NewbornLeydig CellsLuteinizing HormoneMaleRatsRats, WistarReceptors, AndrogenSertoli CellsSpermatogenesisTestosteroneLuteinizing HormoneReceptors, AndrogenTestosteronediabetes mellitusgerm cellsLeydig cellsSertoli cellstestis

Identifiers

PMID41227359
PMCPMC12607479

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.