Evidence map›Paper›PMID 41227356›Full record

ArticleCells2025

Dual ROCK1/2-MYLK4 Kinase Inhibition Preserves Visual Function in a Rat Model of Neuromyelitis Optica Spectrum Disorder Optic Neuritis.

Chin-Te Huang, Monir Hossen, Tu-Wen Chen, Chih-Wei Fu, Yi-Hsun Chen, Tzu-Lun Huang, Rong-Kung Tsai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chin-Te HuangInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.ORCID 0000-0002-8494-7335
Monir HossenInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
Tu-Wen ChenInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.ORCID 0000-0002-3075-4642
Chih-Wei FuBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan.
Yi-Hsun ChenBiomedical Technology and Device Research Laboratories, Industrial Technology Research Institute, Hsinchu 310401, Taiwan.ORCID 0009-0002-2200-6078
Tzu-Lun HuangInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
Rong-Kung TsaiInstitute of Eye Research, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.ORCID 0000-0001-8760-5739

Funding

National Science and Technology Council, Taiwan MOST 111-2635-B-418-001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Neuromyelitis OpticaOptic NeuritisProtein Kinase Inhibitorsrho-Associated KinasesVision, OcularAnimalsApoptosisAquaporin 4Disease Models, AnimalEvoked Potentials, VisualFemaleMaleOptic NerveRatsRats, Sprague-DawleyRetinal Ganglion CellsAquaporin 4Protein Kinase Inhibitorsrho-Associated KinasesROCK2 protein, ratneuroinflammationneuromyelitis opticaoptic neuritisprotein kinase inhibitorsretinal ganglion cells

Identifiers

PMID41227356
PMCPMC12607673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.