Evidence map›Paper›PMID 41227291›Full record

ArticleCells2025

Nicotinamide Counteracts the Detrimental Effect of Endothelin-1 on Uterine Decidualization During Early Pregnancy by Influencing EDNRB.

Yuye Wang, Qing Ma, Meitong Chen, Yukako Kayashima, Jiayi Zhou, Balaji Rao, Jessica L Bowser, Xianwen Yi, Nobuyo Maeda-Smithies, Feng Li

Abstract read
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuye WangDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Qing MaDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Meitong ChenDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Yukako KayashimaDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Jiayi ZhouDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0009-7301-2698
Balaji RaoDepartment of Chemical and Biomolecular Engineering, Golden LEAF Biomanufacturing Training and Education Center, North Carolina State University, Raleigh, NC 27695, USA.
Jessica L BowserDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Xianwen YiDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0001-9320-2020
Nobuyo Maeda-SmithiesDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-2248-3299
Feng LiDepartment of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0002-6779-5077

Funding

MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
Benefits of nicotinamide in placental development and in preeclamsiaR01HD101485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, FENG · 2021 to 2025
$2.1M
NHLBI NIH HHS R01 HL049277NICHD NIH HHS R01 HD101485NIH HHS 1R01HD101485-05
6 · The paper itself

Abstract

Endothelin-1 (ET-1) is involved in the pathogenesis of preeclampsia. Mice (

Indexed as

DeciduaEndothelin-1NiacinamideReceptor, Endothelin BUterusAnimalsEmbryo ImplantationFemaleHumansMiceMice, Inbred C57BLPregnancyEndothelin-1NiacinamideReceptor, Endothelin BdecidualizationEndothelin-1human endometrial stomal cellsmicenicotinamidepreeclampsia

Identifiers

PMID41227291
PMCPMC12608920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.