ReviewInternational journal of molecular sciences2025
Investigating the Epigenetic Therapeutic Potential of Natural Compounds in Cancer.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Chrysin treatment is associated with altered microrna expression and reduced levels of HPV16 E6 protein in caski cervical cancer cells.Medical oncology (Northwood, London, England) · 2026Article
- Bacterioruberin fromInternational journal of molecular sciences · 2026Article
- Natural Products in Prostate Cancer: Crosstalk Among the Gut Microbiome, Androgen Receptor Signaling, and Epigenetic Regulation.International journal of molecular sciences · 2026Review
- Cardiac Modulation byCurrent issues in molecular biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Natural compounds, including alkaloids, terpenes, and polyphenols, are increasingly recognized for their potential to modulate epigenetic mechanisms and influence cellular function, particularly in cancer. Studies have shown that diverse phytochemicals impact epigenetic modifications, such as DNA methylation, histone modifications, and non-coding RNA expression. Epigenetics is critical in cancer and can dysregulate crucial cellular processes, such as cell proliferation, apoptosis, and differentiation. In cancer, aberrant epigenetic patterns can silence tumor suppressor genes and activate oncogenes, contributing to uncontrolled cell growth and metastasis. Understanding the precise mechanisms by which these natural compounds interact with the epigenetic machinery holds significant promise for developing novel therapeutic strategies for cancer and other diseases. Future research, including basic studies and well-designed clinical trials, will be crucial in validating these findings and developing effective clinical applications of natural compounds.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.