Evidence map›Paper›PMID 41226794›Full record

ArticleInternational journal of molecular sciences2025

Elevated Levels of Active GSK3β in the Blood of Patients with Myotonic Dystrophy Type 1 Correlate with Muscle Weakness.

Katherine Jennings, Cuixia Tian, Rebeccah L Brown, Paul S Horn, Benedikt Schoser, Hani Kushlaf, Nikolai A Timchenko, Lubov Timchenko

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katherine JenningsDivision of Neurology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH 45229, USA.
Cuixia TianDivision of Neurology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0003-2010-8142
Rebeccah L BrownDepartment of Pediatrics, University of Cincinnati, 2600 Clifton Ave., Cincinnati, OH 45221, USA.ORCID 0000-0003-1834-4808
Paul S HornDivision of Neurology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH 45229, USA.ORCID 0000-0002-4990-5754
Benedikt SchoserDepartment of Neurology, Friedrich-Baur-Institute, LMU Clinics, Ludwig-Maximilians-University, Ziemssenstr., 80336 Munich, Germany.ORCID 0000-0002-2757-8131
Hani KushlafDepartment of Pediatrics, University of Cincinnati, 2600 Clifton Ave., Cincinnati, OH 45221, USA.ORCID 0000-0002-3786-1133
Nikolai A TimchenkoDepartment of Pediatrics, University of Cincinnati, 2600 Clifton Ave., Cincinnati, OH 45221, USA.
Lubov TimchenkoDivision of Neurology, Cincinnati Children's Hospital, 3333 Burnet Ave., Cincinnati, OH 45229, USA.

Funding

GSK3 beta study in patients with Myotonic Dystrophy 1R01AR073379 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, LUBOV T · 2019 to 2023
$1.8M
CNS in Congenital DM1: Pathogenesis and Therapeutic OpportunitiesR01NS115662 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI TIMCHENKO, LUBOV T · 2020 to 2024
$1.8M
NIAMS NIH HHS R01 AR073379NIH HHS 1R01AR073379-07NIH HHS 1R01NS115662-06NINDS NIH HHS R01 NS115662
6 · The paper itself

Abstract

Myotonic Dystrophy type 1 (DM1) is a complex disease affecting multiple tissues, including skeletal and cardiac muscles, the brain and the eyes. DM1 results from an expansion of CTG repeats in the 3' UTR of the

Indexed as

Glycogen Synthase Kinase 3 betaMuscle WeaknessMyotonic DystrophyAdolescentAdultBiomarkersChildFemaleHumansLeukocytes, MononuclearMaleMiddle AgedMyotonin-Protein KinaseThiadiazolesTrinucleotide Repeat ExpansionYoung AdultBiomarkersGlycogen Synthase Kinase 3 betaGSK3B protein, humanMyotonin-Protein KinaseThiadiazolestideglusibCTG repeatsGSK3β kinaseMyotonic Dystrophy type 1

Identifiers

PMID41226794
PMCPMC12609377

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.