Evidence map›Paper›PMID 41226746›Full record

ArticleInternational journal of molecular sciences2025

Immunomodulatory Effects of a High-CBD Cannabis Extract: A Comparative Analysis with Conventional Therapies for Oral Lichen Planus and Graft-Versus-Host Disease.

Kifah Blal, Ronen Rosenblum, Hila Novak-Kotzer, Shiri Procaccia, Jawad Abu Tair, Nardy Casap, David Meiri, Ofra Benny

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kifah BlalDepartment of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.ORCID 0000-0002-5319-0747
Ronen RosenblumLaboratory of Cancer Biology and Natural Drug Discovery, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Hila Novak-KotzerLaboratory of Cancer Biology and Natural Drug Discovery, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Shiri ProcacciaLaboratory of Cancer Biology and Natural Drug Discovery, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Jawad Abu TairDepartment of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
Nardy CasapDepartment of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.
David MeiriLaboratory of Cancer Biology and Natural Drug Discovery, Faculty of Biology, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
Ofra BennySchool of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.ORCID 0000-0002-2468-5978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the immunomodulatory effects of a well-characterized cannabidiol (CBD)-rich cannabis extract, CAN296, on T lymphocytes (T cells), particularly Cluster of Differentiation 4 (CD4

Indexed as

CannabisGraft vs Host DiseaseImmunologic FactorsLichen Planus, OralPlant ExtractsAdultAntigens, CDAntigens, Differentiation, T-LymphocyteCD4-Positive T-LymphocytesCD69 AntigensCD8-Positive T-LymphocytesCytokinesDexamethasoneFas Ligand ProteinFemaleGranzymesAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCytokinesDexamethasoneFas Ligand ProteinGranzymesImmunologic FactorsInterferon-gammaLectins, C-TypePerforinPlant ExtractsTacrolimusTumor Necrosis Factor-alphacannabidiolcannabisgraft-versus-host diseaseimmunomodulationoral lichen planus

Identifiers

PMID41226746
PMCPMC12609824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.