Evidence map›Paper›PMID 41226745›Full record

ArticleInternational journal of molecular sciences2025

Small Intestine Neuromuscular Dysfunctions and Neurogliopathy in a Mouse Model of High-Fat Diet-Induced Obesity: Involvement of Toll-Like Receptor 4.

Sofia Faggin, Silvia Cerantola, Annalisa Bosi, Cristina Giaroni, Eleonora Napoli, Edoardo Vincenzo Savarino, Martina Contran, Andrea Porzionato, Carolina Pellegrini, Luca Antonioli and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sofia FagginDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0003-4813-2259
Silvia CerantolaDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0001-7099-4475
Annalisa BosiDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.
Cristina GiaroniDepartment of Medicine and Surgery, University of Insubria, 21100 Varese, Italy.ORCID 0000-0002-3760-3441
Eleonora NapoliDepartment of Neurology, School of Medicine, University of California Davis, Sacramento, CA 95817, USA.ORCID 0000-0001-8808-4242
Edoardo Vincenzo SavarinoDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-3187-2894
Martina ContranSection of Human Anatomy, Department of Neuroscience, University of Padova, 35131 Padova, Italy.
Andrea PorzionatoSection of Human Anatomy, Department of Neuroscience, University of Padova, 35131 Padova, Italy.
Carolina PellegriniDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-2644-5430
Luca AntonioliDepartment of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Valentina CaputiDepartment of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0009-0003-7699-702X
Maria Cecilia GironDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, Italy.ORCID 0000-0002-0825-7965

Funding

AlfaWassermann spa MCG_VC2016SC2019AWDSF, University of Padova SC_PostDoc Fellowship ARD-B 2020DSF, University of Padova SF_PostDoc Fellowship ARD-A 2024DSF, University of Padova SF_PostDoc Fellowship ARD-B 2023DSF, University of Padova UNIPD-DSF-PRID-2023European Crohn's and Colitis Organisation ECCO Grant 2022MIUR MUR/University of Padova PhD Fellowship 2020San Camillo Hospital Grant, Treviso SCHG2017
6 · The paper itself

Abstract

Obesity is associated with enteric dysfunctions, including gut dysmotility and neurodegeneration, which may involve Toll-like receptor 4 (TLR4) signaling. To investigate this relationship, we examined the impact of TLR4 deficiency on the enteric nervous system (ENS) of the small intestine in a mouse model of high-fat diet (HFD)-induced obesity. Male TLR4

Indexed as

Diet, High-FatIntestine, SmallNeurogliaObesityToll-Like Receptor 4AnimalsDisease Models, AnimalEnteric Nervous SystemGastrointestinal MotilityMaleMiceMice, Inbred C57BLMice, KnockoutMyenteric PlexusTlr4 protein, mouseToll-Like Receptor 4enteric nervous systemhigh-fat dietinflammationneurodegenerationobesityserotoninToll-like receptor 4

Identifiers

PMID41226745
PMCPMC12608152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.