Evidence map›Paper›PMID 41226744›Full record

ArticleInternational journal of molecular sciences2025

Sialylation Inhibition Impairs Migration and Promotes Adhesion of GBM Cells.

Deborah Gargano, Mariangela Calvitto, Antonella Niro, Giuseppe Pepe, Noemi Martella, Alessia Tani, Paolo Rosa, Vittorio Maglione, Giovanni Musci, Antimo Cutone and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Deborah GarganoDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0009-0009-9271-9613
Mariangela CalvittoDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0009-0006-0807-4102
Antonella NiroDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.
Giuseppe PepeNeuromed IRCCS, Via Dell'Elettronica, 86077 Pozzilli, Italy.
Noemi MartellaDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0003-0455-1494
Alessia TaniDepartment of Experimental and Clinical Medicine, Section of Anatomy and Histology, Imaging Platform, University of Florence, 50134 Florence, Italy.ORCID 0000-0001-7992-0237
Paolo RosaDepartment of Medical-Surgical Sciences and Biotechnologies, University of Rome "Sapienza", Polo Pontino, 04100 Latina, Italy.ORCID 0000-0002-8468-0677
Vittorio MaglioneNeuromed IRCCS, Via Dell'Elettronica, 86077 Pozzilli, Italy.
Giovanni MusciDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-5196-709X
Antimo CutoneDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-7492-8616
Sabrina Di BartolomeoDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-5748-1541
Eleonora SgambatiDepartment of Biosciences and Territory, University of Molise, 86090 Pesche, Italy.ORCID 0000-0002-1487-6463

Funding

University of Molise not available
6 · The paper itself

Abstract

Aberrant sialylation has been associated with many types of tumors, characterized by aggressiveness and undifferentiated state. However, not exhaustive investigations have been performed on the sialylation status in glioblastoma multiforme (GBM), the most common primary and lethal malignant brain tumor in humans. Hence, in this study we performed a comprehensive characterization of the sialylation status in GBM evaluating specific sialyltransferases and various types of sialic acids (Sias) in different GBM cell lines. First, through in silico analysis we showed that the sialyltransferases

Indexed as

Brain NeoplasmsCell AdhesionCell MovementGlioblastomaSialic AcidsSialyltransferasesAntigens, CDbeta-D-Galactoside alpha 2-6-Sialyltransferasebeta-Galactoside alpha-2,3-SialyltransferaseCell Line, TumorGene Expression Regulation, NeoplasticHumansN-Acetylneuraminic AcidAntigens, CDbeta-D-Galactoside alpha 2-6-Sialyltransferasebeta-Galactoside alpha-2,3-SialyltransferaseN-Acetylneuraminic AcidSialic AcidsSialyltransferasesST6GAL1 protein, humanST8SIA4 protein, human3-Fax-peracetyl-Neu5Accell adhesioncell migrationglioblastoma multiformesialic acidssialyltransferases

Identifiers

PMID41226744
PMCPMC12611029

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.