Evidence map›Paper›PMID 41226734›Full record

ArticleInternational journal of molecular sciences2025

Xanthohumol Alters Gut Microbiota Metabolism and Bile Acid Dynamics in Gastrointestinal Simulation Models of Eubiotic and Dysbiotic States.

Paige E Jamieson, Nicholas J Reichart, Claudia S Maier, Thomas J Sharpton, Ryan Bradley, Thomas O Metz, Jan F Stevens

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paige E JamiesonCollege of Health, Oregon State University, Corvallis, OR 97331, USA.
Nicholas J ReichartEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.ORCID 0000-0002-3901-2039
Claudia S MaierLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.
Thomas J SharptonDepartment of Microbiology, Oregon State University, Corvallis, OR 97331, USA.
Ryan BradleyHelfgott Research Institute, National University of Natural Medicine, Portland, OR 97201, USA.
Thomas O MetzEarth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352, USA.ORCID 0000-0001-6049-3968
Jan F StevensLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-6348-9347

Funding

Discovery and Biological Signatures of Microbiome-Derived Xanthohumol Metabolites and their Role in Ameliorating Inflammatory Bowel DiseaseR01AT010271 · NCCIH · OREGON STATE UNIVERSITY · PI BRADLEY, RYAN D, METZ, THOMAS O · 2018 to 2021
$1.8M
Ultra-Performance Liquid Chromatography Tandem Quadrupole Mass Spectrometry SystemS10OD026922 · OD · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S · 2019 to 2019
$577k
Triple Quadrupole/Linear Ion Trap LC-MS/MS for LPIS10RR027878 · NCRR · OREGON STATE UNIVERSITY · PI STEVENS, JAN FREDERIK · 2010 to 2010
$484k
NCCIH NIH HHS R01 AT010271NCRR NIH HHS S10 RR027878NIH HHS R01AT010271NIH HHS S10 OD026922NIH HHS S10OD026922NIH HHS S10RR027878
6 · The paper itself

Abstract

Xanthohumol (XN), a polyphenol from hops (

Indexed as

Bile Acids and SaltsDysbiosisFlavonoidsGastrointestinal MicrobiomePropiophenonesBacteriaFatty Acids, VolatileHumansHumulusMaleRNA, Ribosomal, 16SBile Acids and SaltsFatty Acids, VolatileFlavonoidsPropiophenonesRNA, Ribosomal, 16Sxanthohumolbile acidsdysbiosisgut microbiotaHumulus lupulusphytochemicalpolyphenolSHIMExanthohumol

Identifiers

PMID41226734
PMCPMC12608232

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.