ArticleInternational journal of molecular sciences2025
Transient Receptor Potential Vanilloid 4 (TRPV4) in the Human Carotid Body.
Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic Vulnerabilities of the Key Genetic Drivers in Leiomyosarcoma.Medical sciences (Basel, Switzerland) · 2026Review
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRPV4 (transient receptor potential vanilloid 4) is a non-selective, multifunctional cationic channel that is expressed in numerous cells in the body. It can be activated by temperature, mechanical forces, and chemical and biochemical molecules. Functionally, TRPV4 participates in maintaining osmotic homeostasis, blood pressure, and hypoxic preconditioning. As far as we know, the presence of TRPV4 has never been reported in the carotid body despite the overlap that exists between some biological functions of TRPV4 and the physiology of the carotid body. In the present work, immunofluorescence associated with confocal laser microscopy, associated with quantitative analysis (area occupied by immunofluorescence), has been used to examine the occurrence of TRPV4 in the human carotid body. The results demonstrated the presence of TRPV4 in a subpopulation of chemoreceptor type I cells (approximately 65-68%), a subpopulation of type II supporting cells, and in nerve terminals in the human carotid body. Its function, if any, in this multisensory organ must be demonstrated, but it is in line with the functions attributed to the carotid body.
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Registered trials
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