Evidence map›Paper›PMID 41226724›Full record

ArticleInternational journal of molecular sciences2025

Lipidomic Signature of Patients with Familial Hypercholesterolemia Carrying Pathogenic Variants Unveils a Cue of Increased Cardiovascular Risk.

Giulia De Simone, Maria Donata Di Taranto, Debora Paris, Martina Ferrandino, Marco Andolfi, Annalaura Iodice, Giovanna Cardiero, Carmine De Luca, Luigi Junior Valletta, Ilenia Lorenza Calcaterra and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Giulia De SimoneConsiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0002-4894-3708
Maria Donata Di TarantoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.ORCID 0000-0002-0618-7940
Debora ParisConsiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0003-4526-8353
Martina FerrandinoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.
Marco AndolfiConsiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.
Annalaura IodiceConsiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0009-0008-7283-2152
Giovanna CardieroDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.ORCID 0009-0009-5615-298X
Carmine De LucaDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.ORCID 0009-0004-6875-9133
Luigi Junior VallettaDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.
Ilenia Lorenza CalcaterraDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.
Gabriella IannuzzoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.ORCID 0000-0002-7392-5544
Matteo Nicola Dario Di MinnoDipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.ORCID 0000-0001-8059-3819
Giuliana FortunatoDipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Via Pansini 5, 80131 Napoli, Italy.
Adele CutignanoConsiglio Nazionale delle Ricerche (CNR), Istituto di Chimica Biomolecolare (ICB), Via Campi Flegrei 34, 80078 Pozzuoli, Italy.ORCID 0000-0003-3035-9252

Funding

Ministero dell'università e della ricerca PRIN 2022 PROT. 2022572TTW
6 · The paper itself

Abstract

Familial Hypercholesterolemia (FH) is a common genetic disorder characterized by elevated LDL-cholesterol levels and an increased risk of premature cardiovascular disease. While pathogenic variants in

Indexed as

Cardiovascular DiseasesHyperlipoproteinemia Type IILipidomicsLipidsAdultFemaleHumansMaleMetabolomeMetabolomicsMiddle AgedProprotein Convertase 9Receptors, LDLLipidsProprotein Convertase 9Receptors, LDLdyslipidemialipidomicsliquid chromatography-mass spectrometrynuclear magnetic resonancesphingomyelins

Identifiers

PMID41226724
PMCPMC12609719

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.