Evidence map›Paper›PMID 41226675›Full record

ArticleInternational journal of molecular sciences2025

Integrated Transcriptome and Metabolome Analysis Identifies Key Genes Regulating Maize Tolerance to Alkaline Stress.

Shouxu Liu, Zichang Jia, Xuanxuan Hou, Xue Yang, Fazhan Qiu, Meisam Zargar, Moxian Chen, Congming Lu, Yinggao Liu

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shouxu LiuNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.
Zichang JiaState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Xuanxuan HouNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.
Xue YangState Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China.
Fazhan QiuNational Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-0709-9635
Meisam ZargarDepartment of Agrobiotechnology, Institute of Agriculture, Peoples' Friendship University of Russia, Moscow 117198, Russia.ORCID 0000-0002-5208-0861
Moxian ChenNational Key Laboratory for the Development and Utilization of Forest Food Resources, State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of State Forestry and Grassland Administration on Subtropical Forest Biodiversity Conservation, The Southern Modern Forestry Collaborative Innovation Center, College of Life Sciences, Nanjing Forestry University, Nanjing 210037, China.
Congming LuNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.ORCID 0000-0002-0337-4070
Yinggao LiuNational Key Laboratory of Wheat Improvement, College of Life Sciences, Shandong Agricultural University, Tai'an 271018, China.ORCID 0009-0006-0101-4174

Funding

National Natural Science Foundation of China No. 32460524RUDN University Scientific Projects Grant System No. 040416‑2‑000
6 · The paper itself

Abstract

Soil salinization threatens global food security, necessitating the development of saline-alkaline-tolerant crops. This study investigated the molecular mechanisms of alkali stress tolerance in maize. Screening 369 inbred lines identified two alkali-resistant and two alkali-sensitive varieties. Systematic analysis revealed that resistant varieties rapidly lowered rhizosphere pH and maintained root architecture, whereas sensitive varieties suffered reduced lateral roots and severe biomass loss. Metabolomic profiling showed that all varieties secreted malonic acid via the pyrimidine pathway to modulate rhizosphere pH, with resistant varieties exhibiting stronger accumulation. Transcriptome and RT-qPCR analysis identified two key genes:

Indexed as

AlkaliesMetabolomeStress, PhysiologicalTranscriptomeZea maysGene Expression ProfilingGene Expression Regulation, PlantHydrogen-Ion ConcentrationMalonatesPlant ProteinsPlant RootsRhizosphereAlkaliesMalonatesmalonic acidPlant Proteinsalkaline stressmaizemetabolomeorganic acidsroot systemtranscriptome

Identifiers

PMID41226675
PMCPMC12607767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.