ReviewInternational journal of molecular sciences2025
Current Insights and Future Directions in Scar Management and Skin Regeneration.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Add-on benefits of botulinum toxin type A in combination or sequential therapies for scar management: a systematic review and meta-analysis.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- An adhesive hydrogel enabling spatiotemporal delivery of umbilical cord exosomes for scarless skin regeneration through immunomodulation and ECM remodeling.Bioactive materials · 2027Article
- Angiotensin II as a Novel Biomarker in the Assessment and Prediction of Post-burn Hypertrophic Scarring: A Propensity Score-Matched Cohort Study.Aesthetic plastic surgery · 2026Article
- Enhancing Antibacterial Activity ofPharmaceuticals (Basel, Switzerland) · 2026Article
- Gingival Thickness Improvement After Atelocollagen Injection-Retrospective Study.Life (Basel, Switzerland) · 2026Article
- Fisetin promotes skin wound healing and inhibits pathological scar formation through modulation of the PI3K/Akt/TGF-β1 signaling axis.Frontiers in pharmacology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Skin scarring, including hypertrophic scars and keloids, often results from dysregulated collagen deposition during wound healing. Tropocollagen (TC), the soluble triple-helical precursor of collagen fibers, serves as the fundamental structural unit of the extracellular matrix (ECM) and plays a pivotal role in tissue repair. This review summarizes current knowledge on collagen and TC in wound healing, scar management, and regenerative dermatology. TC self-assembles into fibrils, providing structural support, while interacting with fibroblasts and growth factors such as transforming growth factor beta (TGF-β) and vascular endothelial growth factor (VEGF) to regulate ECM remodeling, angiogenesis, and tissue regeneration. Various collagen preparations, including hydrolyzed collagen, gelatin, and native fibrillar forms, differ in molecular structure, bioavailability, and therapeutic applications. Emerging strategies, including collagen- and TC-based hydrogels, nanomaterial composites, and smart wound dressings, enhance stability, targeted delivery, and clinical efficacy. Despite promising preclinical and early clinical data, standardized preparations and robust randomized trials are needed to validate TC's therapeutic potential and optimize its application in scar prevention and wound repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.